Acylaminoacyl-peptidase

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Acylaminoacyl-peptidase (EC 3.4.19.1, acylamino-acid-releasing enzyme, N-acylpeptide hydrolase, N-formylmethionine (fMet) aminopeptidase, alpha-N-acylpeptide hydrolase) is an enzyme.^[1]^[2]^[3] This enzyme catalyses the following chemical reaction

Cleavage of an N-acetyl or N-formyl amino acid from the N-terminus of a polypeptide

This enzyme is active at neutral pH.

References

↑ Tsunazawa, S., Narita, K. and Ogata, K. (1975). "Acylamino acid-releasing enzyme from rat liver". J. Biochem. (Tokyo) 77: 89–102. PMID 1137989.
↑ Ungar, T., Nagelschmidt, M. and Struck, H. (1979). "N-Acetylaminoacyl-p-nitranilidase from human placenta. Purification and some properties". Eur. J. Biochem. 97: 205–211. doi:10.1111/j.1432-1033.1979.tb13104.x. PMID 477668.
↑ Kobayashi, K. and Smith, J.A. (1987). "Acyl-peptide hydrolase from rat liver. Characterization of enzyme reaction". J. Biol. Chem. 262: 11435–11437. PMID 3305492.

External links

Acylaminoacyl-peptidase at the US National Library of Medicine Medical Subject Headings (MeSH)

Hydrolase: proteases (EC 3.4)

3.4.11-19: Exopeptidase

3.4.11	Aminopeptidase Alanine Arginyl Aspartyl Cystinyl Leucyl Glutamyl Methionyl 1 2 O

3.4.13	Dipeptidase 1 2 3

3.4.14	Dipeptidyl peptidase Cathepsin C Dipeptidyl peptidase-4 Tripeptidyl peptidase Tripeptidyl peptidase I Tripeptidyl peptidase II

3.4.15	Angiotensin-converting enzyme

3.4.16	Serine type carboxypeptidases: Cathepsin A DD-transpeptidase

3.4.17	Metalloexopeptidases Carboxypeptidase A A2 B C E Glutamate II

Other/ungrouped	Metalloexopeptidase

3.4.21-25: Endopeptidase

Other/ungrouped: Amyloid precursor protein secretase

3.4.99: Unknown

Staphylokinase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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