Aminopeptidase Y

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Aminopeptidase Y (EC 3.4.11.15, aminopeptidase Co, aminopeptidase (cobalt-activated), lysyl aminopeptidase) is an enzyme.^[1]^[2]^[3] This enzyme catalyses the following chemical reaction

Preferentially, release of N-terminal lysine

This enzyme requires Co²⁺. It is inhibited by Zn²⁺ and Mn²⁺.

References

↑ Achstetter, T., Ehmann, C. and Wolf, D.H. (1982). "Aminopeptidase Co, a new yeast peptidase". Biochem. Biophys. Res. Commun. 109: 341–347. doi:10.1016/0006-291x(82)91726-0. PMID 6758786.
↑ Yasuhara, T., Nakai, T. and Ohashi, A. (1994). "Aminopeptidase Y, a new aminopeptidase from Saccharomyces cerevisiae. Purification, properties, localization, and processing by protease B". J. Biol. Chem. 269: 13644–13650. PMID 8175799.
↑ Nishizawa, M., Yasuhara, T., Nakai, T., Fujiki, Y. and Ohashi, A. (1994). "Molecular cloning of the aminopeptidase Y gene of Saccharomyces cerevisiae. Sequence analysis and gene disruption of a new aminopeptidase". J. Biol. Chem. 269: 13651–13655. PMID 8175800.

External links

Aminopeptidase Y at the US National Library of Medicine Medical Subject Headings (MeSH)

Hydrolase: proteases (EC 3.4)

3.4.11-19: Exopeptidase

3.4.11	Aminopeptidase Alanine Arginyl Aspartyl Cystinyl Leucyl Glutamyl Methionyl 1 2 O

3.4.13	Dipeptidase 1 2 3

3.4.14	Dipeptidyl peptidase Cathepsin C Dipeptidyl peptidase-4 Tripeptidyl peptidase Tripeptidyl peptidase I Tripeptidyl peptidase II

3.4.15	Angiotensin-converting enzyme

3.4.16	Serine type carboxypeptidases: Cathepsin A DD-transpeptidase

3.4.17	Metalloexopeptidases Carboxypeptidase A A2 B C E Glutamate II

Other/ungrouped	Metalloexopeptidase

3.4.21-25: Endopeptidase

Other/ungrouped: Amyloid precursor protein secretase

3.4.99: Unknown

Staphylokinase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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