BIN1

Bridging integrator 1
PDB rendering based on 1bb9.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1MUZ​, 1MV0​, 1MV3​, 2FIC​, 2RMY​, 2RND​
Identifiers
Symbols	BIN1 ; AMPH2; AMPHL; SH3P9
External IDs	OMIM: 601248 MGI: 108092 HomoloGene: 113707 GeneCards: BIN1 Gene
Gene ontology Molecular function • protein binding • identical protein binding • tau protein binding • RNA polymerase binding Cellular component • nucleus • cytoplasm • actin cytoskeleton • membrane • Z disc • T-tubule • axon • I band • node of Ranvier • axon initial segment • lipid tube Biological process • endocytosis • cell proliferation • viral process • regulation of endocytosis • muscle cell differentiation • positive regulation of apoptotic process • regulation of neuron differentiation • positive regulation of astrocyte differentiation • lipid tube assembly • regulation of cell cycle arrest Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	274	30948
Ensembl	ENSG00000136717	ENSMUSG00000024381
UniProt	O00499	O08539
RefSeq (mRNA)	NM_004305	NM_001083334
RefSeq (protein)	NP_004296	NP_001076803
Location (UCSC)	Chr 2: 127.05 – 127.11 Mb	Chr 18: 32.38 – 32.44 Mb
PubMed search

Myc box-dependent-interacting protein 1 is a protein that in humans is encoded by the BIN1 gene.^[1][2][3]

This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynanim, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.^[4]

Interactions

BIN1 has been shown to interact with Phospholipase D1,^[5] SNX4^[6] and PLD2.^[5]

References

1. Negorev D, Riethman H, Wechsler-Reya R, Sakamuro D, Prendergast GC, Simon D (January 1997). "The Bin1 gene localizes to human chromosome 2q14 by PCR analysis of somatic cell hybrids and fluorescence in situ hybridization". Genomics 33 (2): 329–31. doi:10.1006/geno.1996.0205. PMID 8725406.
2. Sakamuro D, Elliott KJ, Wechsler-Reya R, Prendergast GC (October 1996). "BIN1 is a novel MYC-interacting protein with features of a tumour suppressor". Nat Genet 14 (1): 69–77. doi:10.1038/ng0996-69. PMID 8782822.
3. Nicot AS, Toussaint A, Tosch V, Kretz C, Wallgren-Pettersson C, Iwarsson E, Kingston H, Garnier JM, Biancalana V, Oldfors A, Mandel JL, Laporte J (August 2007). "Mutations in amphiphysin 2 (BIN1) disrupt interaction with dynamin 2 and cause autosomal recessive centronuclear myopathy". Nat Genet 39 (9): 1134–9. doi:10.1038/ng2086. PMID 17676042.
4. "Entrez Gene: BIN1 bridging integrator 1".
5. Lee, C; Kim S R; Chung J K; Frohman M A; Kilimann M W; Rhee S G (June 2000). "Inhibition of phospholipase D by amphiphysins". J. Biol. Chem. (UNITED STATES) 275 (25): 18751–8. doi:10.1074/jbc.M001695200. ISSN 0021-9258. PMID 10764771.
6. Leprince, Corinne; Le Scolan Erwan; Meunier Brigitte; Fraisier Vincent; Brandon Nathalie; De Gunzburg Jean; Camonis Jacques (May 2003). "Sorting nexin 4 and amphiphysin 2, a new partnership between endocytosis and intracellular trafficking". J. Cell. Sci. (England) 116 (Pt 10): 1937–48. doi:10.1242/jcs.00403. ISSN 0021-9533. PMID 12668730.

Further reading

• Andersson B, Wentland MA, Ricafrente JY; et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC; et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Leprince C, Romero F, Cussac D; et al. (1997). "A new member of the amphiphysin family connecting endocytosis and signal transduction pathways". J. Biol. Chem. 272 (24): 15101–5. doi:10.1074/jbc.272.24.15101. PMID 9182529.
• Butler MH, David C, Ochoa GC; et al. (1997). "Amphiphysin II (SH3P9; BIN1), a Member of the Amphiphysin/Rvs Family, Is Concentrated in the Cortical Cytomatrix of Axon Initial Segments and Nodes of Ranvier in Brain and around T Tubules in Skeletal Muscle". J. Cell Biol. 137 (6): 1355–67. doi:10.1083/jcb.137.6.1355. PMC 2132527. PMID 9182667.
• Ramjaun AR, Micheva KD, Bouchelet I, McPherson PS (1997). "Identification and characterization of a nerve terminal-enriched amphiphysin isoform". J. Biol. Chem. 272 (26): 16700–6. doi:10.1074/jbc.272.26.16700. PMID 9195986.
• Tsutsui K, Maeda Y, Tsutsui K; et al. (1997). "cDNA cloning of a novel amphiphysin isoform and tissue-specific expression of its multiple splice variants". Biochem. Biophys. Res. Commun. 236 (1): 178–83. doi:10.1006/bbrc.1997.6927. PMID 9223448.
• McMahon HT, Wigge P, Smith C (1997). "Clathrin interacts specifically with amphiphysin and is displaced by dynamin". FEBS Lett. 413 (2): 319–22. doi:10.1016/S0014-5793(97)00928-9. PMID 9280305.
• Micheva KD, Ramjaun AR, Kay BK, McPherson PS (1997). "SH3 domain-dependent interactions of endophilin with amphiphysin". FEBS Lett. 414 (2): 308–12. doi:10.1016/S0014-5793(97)01016-8. PMID 9315708.
• Micheva KD, Kay BK, McPherson PS (1997). "Synaptojanin forms two separate complexes in the nerve terminal. Interactions with endophilin and amphiphysin". J. Biol. Chem. 272 (43): 27239–45. doi:10.1074/jbc.272.43.27239. PMID 9341169.
• Wigge P, Köhler K, Vallis Y; et al. (1997). "Amphiphysin Heterodimers: Potential Role in Clathrin-mediated Endocytosis". Mol. Biol. Cell 8 (10): 2003–15. doi:10.1091/mbc.8.10.2003. PMC 25662. PMID 9348539.
• Kadlec L, Pendergast AM (1997). "The amphiphysin-like protein 1 (ALP1) interacts functionally with the cABL tyrosine kinase and may play a role in cytoskeletal regulation". Proc. Natl. Acad. Sci. U.S.A. 94 (23): 12390–5. doi:10.1073/pnas.94.23.12390. PMC 24959. PMID 9356459.
• Wechsler-Reya R, Sakamuro D, Zhang J; et al. (1998). "Structural analysis of the human BIN1 gene. Evidence for tissue-specific transcriptional regulation and alternate RNA splicing". J. Biol. Chem. 272 (50): 31453–8. doi:10.1074/jbc.272.50.31453. PMID 9395479.
• Wechsler-Reya RJ, Elliott KJ, Prendergast GC (1998). "A Role for the Putative Tumor Suppressor Bin1 in Muscle Cell Differentiation". Mol. Cell. Biol. 18 (1): 566–75. PMC 121524. PMID 9418903.
• Ramjaun AR, McPherson PS (1998). "Multiple amphiphysin II splice variants display differential clathrin binding: identification of two distinct clathrin-binding sites". J. Neurochem. 70 (6): 2369–76. doi:10.1046/j.1471-4159.1998.70062369.x. PMID 9603201.
• Mao NC, Steingrimsson E, DuHadaway J; et al. (1999). "The murine Bin1 gene functions early in myogenesis and defines a new region of synteny between mouse chromosome 18 and human chromosome 2". Genomics 56 (1): 51–8. doi:10.1006/geno.1998.5709. PMID 10036185.
• Wixler V, Laplantine E, Geerts D; et al. (1999). "Identification of novel interaction partners for the conserved membrane proximal region of alpha-integrin cytoplasmic domains". FEBS Lett. 445 (2–3): 351–5. doi:10.1016/S0014-5793(99)00151-9. PMID 10094488.
• Ramjaun AR, Philie J, de Heuvel E, McPherson PS (1999). "The N terminus of amphiphysin II mediates dimerization and plasma membrane targeting". J. Biol. Chem. 274 (28): 19785–91. doi:10.1074/jbc.274.28.19785. PMID 10391921.
• Traub LM, Downs MA, Westrich JL, Fremont DH (1999). "Crystal structure of the α appendage of AP-2 reveals a recruitment platform for clathrin-coat assembly". Proc. Natl. Acad. Sci. U.S.A. 96 (16): 8907–12. doi:10.1073/pnas.96.16.8907. PMC 17706. PMID 10430869.