SNX4

Sorting nexin 4
Identifiers
Symbols	SNX4 ; ATG24B
External IDs	OMIM: 605931 MGI: 1916400 HomoloGene: 36143 GeneCards: SNX4 Gene
Gene ontology Molecular function • epidermal growth factor receptor binding • insulin receptor binding • protein binding • phosphatidylinositol binding • transferrin receptor binding • leptin receptor binding Cellular component • cytoplasm • endosome • cytoplasmic dynein complex • plasma membrane • membrane • extrinsic component of membrane • SNARE complex • early endosome membrane • protein complex Biological process • endocytosis • protein transport • vesicle organization • endocytic recycling • positive regulation of histamine secretion by mast cell Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8723	69150
Ensembl	ENSG00000114520	ENSMUSG00000022808
UniProt	O95219	Q91YJ2
RefSeq (mRNA)	NM_003794	NM_080557
RefSeq (protein)	NP_003785	NP_542124
Location (UCSC)	Chr 3: 125.45 – 125.52 Mb	Chr 16: 33.25 – 33.3 Mb
PubMed search

Sorting nexin-4 is a protein that in humans is encoded by the SNX4 gene.^[1][2]

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associated with the long isoform of the leptin receptor and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor in cell cultures, but its function is unknown. This protein may form oligomeric complexes with family members.^[2]

Interactions

SNX4 has been shown to interact with BIN1.^[3]

References

1. Haft CR, de la Luz Sierra M, Barr VA, Haft DH, Taylor SI (Dec 1998). "Identification of a family of sorting nexin molecules and characterization of their association with receptors". Mol Cell Biol 18 (12): 7278–87. PMC 109309. PMID 9819414.
2. "Entrez Gene: SNX4 sorting nexin 4".
3. Leprince, Corinne; Le Scolan Erwan; Meunier Brigitte; Fraisier Vincent; Brandon Nathalie; De Gunzburg Jean; Camonis Jacques (May 2003). "Sorting nexin 4 and amphiphysin 2, a new partnership between endocytosis and intracellular trafficking". J. Cell. Sci. (England) 116 (Pt 10): 1937–48. doi:10.1242/jcs.00403. ISSN 0021-9533. PMID 12668730.

Further reading

• Traer CJ, Rutherford AC, Palmer KJ, et al. (2008). "SNX4 coordinates endosomal sorting of TfnR with dynein-mediated transport into the endocytic recycling compartment.". Nat. Cell Biol. 9 (12): 1370–80. doi:10.1038/ncb1656. PMID 17994011.
• Skånland SS, Wälchli S, Utskarpen A, et al. (2007). "Phosphoinositide-regulated retrograde transport of ricin: crosstalk between hVps34 and sorting nexins.". Traffic 8 (3): 297–309. doi:10.1111/j.1600-0854.2006.00527.x. PMID 17319803.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Leprince C, Le Scolan E, Meunier B, et al. (2004). "Sorting nexin 4 and amphiphysin 2, a new partnership between endocytosis and intracellular trafficking.". J. Cell. Sci. 116 (Pt 10): 1937–48. doi:10.1242/jcs.00403. PMID 12668730.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Parks WT, Frank DB, Huff C, et al. (2001). "Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases.". J. Biol. Chem. 276 (22): 19332–9. doi:10.1074/jbc.M100606200. PMID 11279102.