SNX27

Sorting nexin family member 27
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4HAS​
Identifiers
Symbols	SNX27 ; MRT1; MY014
External IDs	OMIM: 611541 MGI: 1923992 HomoloGene: 12797 GeneCards: SNX27 Gene
Gene ontology Molecular function • protein binding • phosphatidylinositol-3-phosphate binding Cellular component • immunological synapse • nucleoplasm • cytoplasm • early endosome • cytosol • retromer complex • early endosome membrane • WASH complex Biological process • establishment of natural killer cell polarity • intracellular protein transport • signal transduction • endosomal transport • response to drug • retrograde transport, endosome to plasma membrane Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	81609	76742
Ensembl	ENSG00000143376	ENSMUSG00000028136
UniProt	Q96L92	Q3UHD6
RefSeq (mRNA)	NM_030918	NM_001082484
RefSeq (protein)	NP_112180	NP_001075953
Location (UCSC)	Chr 1: 151.61 – 151.7 Mb	Chr 3: 94.5 – 94.58 Mb
PubMed search

Sorting nexin family member 27, also known as SNX27, is a human gene.^[1]

This gene encodes a member of the sorting nexin family, a diverse group of cytoplasmic and membrane-associated proteins involved in endocytosis of plasma membrane receptors and protein trafficking through these compartments. All members of this protein family contain a phosphoinositide binding domain (PX domain). A highly similar protein in mice is responsible for the specific recruitment of an isoform of the serotonin 5-hydroxytryptamine 4 receptor into early endosomes, suggesting the analogous role for the human protein.^[1] "Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome" by Xin Wang et al. was published in Nature Medicine on March 24, 2013.

References

1. "Entrez Gene: SNX27 sorting nexin family member 27".

Further reading

• Worby CA, Dixon JE (2003). "Sorting out the cellular functions of sorting nexins". Nat. Rev. Mol. Cell Biol. 3 (12): 919–31. doi:10.1038/nrm974. PMID 12461558.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Seki N, Ohira M, Nagase T, et al. (1998). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Res. 4 (5): 345–9. doi:10.1093/dnares/4.5.345. PMID 9455484.
• Teasdale RD, Loci D, Houghton F, et al. (2001). "A large family of endosome-localized proteins related to sorting nexin 1". Biochem. J. 358 (Pt 1): 7–16. doi:10.1042/0264-6021:3580007. PMC 1222026. PMID 11485546.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Williams R, Schlüter T, Roberts MS, et al. (2005). "Sorting Nexin 17 Accelerates Internalization Yet Retards Degradation of P-selectin". Mol. Biol. Cell 15 (7): 3095–105. doi:10.1091/mbc.E04-02-0143. PMC 452567. PMID 15121882.
• Joubert L, Hanson B, Barthet G, et al. (2005). "New sorting nexin (SNX27) and NHERF specifically interact with the 5-HT4a receptor splice variant: roles in receptor targeting". J. Cell. Sci. 117 (Pt 22): 5367–79. doi:10.1242/jcs.01379. PMID 15466885.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
• Rincón E, Santos T, Avila-Flores A, et al. (2007). "Proteomics identification of sorting nexin 27 as a diacylglycerol kinase zeta-associated protein: new diacylglycerol kinase roles in endocytic recycling". Mol. Cell Proteomics 6 (6): 1073–87. doi:10.1074/mcp.M700047-MCP200. PMID 17351151.
• MacNeil AJ, Mansour M, Pohajdak B (2007). "Sorting nexin 27 interacts with the Cytohesin associated scaffolding protein (CASP) in lymphocytes". Biochem. Biophys. Res. Commun. 359 (4): 848–53. doi:10.1016/j.bbrc.2007.05.162. PMID 17577583.