SNX13
| Sorting nexin 13 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | SNX13 ; RGS-PX1 | ||||||||||||
| External IDs | OMIM: 606589 MGI: 2661416 HomoloGene: 41011 GeneCards: SNX13 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 23161 | 217463 | |||||||||||
| Ensembl | ENSG00000071189 | ENSMUSG00000020590 | |||||||||||
| UniProt | Q9Y5W8 | Q6PHS6 | |||||||||||
| RefSeq (mRNA) | NM_015132 | NM_001014973 | |||||||||||
| RefSeq (protein) | NP_055947 | NP_001014973 | |||||||||||
| Location (UCSC) |
Chr 7: 17.79 – 17.94 Mb |
Chr 12: 35.05 – 35.15 Mb | |||||||||||
| PubMed search | |||||||||||||
Sorting nexin-13 is a protein that in humans is encoded by the SNX13 gene.[1][2][3]
This gene encodes a PHOX domain- and RGS domain-containing protein that belongs to the sorting nexin (SNX) family and the regulator of G protein signaling (RGS) family. The PHOX domain is a phosphoinositide binding domain, and the SNX family members are involved in intracellular trafficking. The RGS family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. The RGS domain of this protein interacts with G alpha(s), accelerates its GTP hydrolysis, and attenuates G alpha(s)-mediated signaling. Overexpression of this protein delayes lysosomal degradation of the epidermal growth factor receptor. Because of its bifunctional role, this protein may link heterotrimeric G protein signaling and vesicular trafficking.[3]
References
- ↑ Teasdale RD, Loci D, Houghton F, Karlsson L, Gleeson PA (Aug 2001). "A large family of endosome-localized proteins related to sorting nexin 1". Biochem J 358 (Pt 1): 7–16. doi:10.1042/0264-6021:3580007. PMC 1222026. PMID 11485546.
- ↑ Zheng B, Ma YC, Ostrom RS, Lavoie C, Gill GN, Insel PA, Huang XY, Farquhar MG (Nov 2001). "RGS-PX1, a GAP for GalphaS and sorting nexin in vesicular trafficking". Science 294 (5548): 1939–42. doi:10.1126/science.1064757. PMID 11729322.
- 1 2 "Entrez Gene: SNX13 sorting nexin 13".
Further reading
- Worby CA, Dixon JE (2003). "Sorting out the cellular functions of sorting nexins". Nat. Rev. Mol. Cell Biol. 3 (12): 919–31. doi:10.1038/nrm974. PMID 12461558.
- Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
- Kosan C, Kunz J (2003). "Identification and characterisation of the gene TWIST NEIGHBOR (TWISTNB) located in the microdeletion syndrome 7p21 region". Cytogenet. Genome Res. 97 (3–4): 167–70. doi:10.1159/000066618. PMID 12438708.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMC 395752. PMID 14759258.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
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