SNX9

Sorting nexin 9
Rendering based on PDB 2RAI​.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2RAI​, 2RAJ​, 2RAK​, 3DYT​, 3DYU​, 3LGE​
Identifiers
Symbols	SNX9 ; SDP1; SH3PX1; SH3PXD3A; WISP
External IDs	OMIM: 605952 MGI: 1913866 HomoloGene: 49454 GeneCards: SNX9 Gene
Gene ontology Molecular function • protein binding • 1-phosphatidylinositol binding • ubiquitin protein ligase binding • phosphatidylinositol binding • protein homodimerization activity • Arp2/3 complex binding Cellular component • ruffle • cytoplasm • endosome • trans-Golgi network • plasma membrane • cytoplasmic membrane-bounded vesicle • clathrin-coated vesicle • cytoplasmic vesicle membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome Biological process • mitotic cytokinesis • intracellular protein transport • endocytosis • receptor-mediated endocytosis • mitotic nuclear division • vesicle organization • endosomal transport • positive regulation of protein oligomerization • cleavage furrow formation • positive regulation of GTPase activity • positive regulation of protein kinase activity • positive regulation of membrane protein ectodomain proteolysis • lipid tube assembly • membrane tubulation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51429	66616
Ensembl	ENSG00000130340	ENSMUSG00000002365
UniProt	Q9Y5X1	Q91VH2
RefSeq (mRNA)	NM_016224	NM_025664
RefSeq (protein)	NP_057308	NP_079940
Location (UCSC)	Chr 6: 157.7 – 157.95 Mb	Chr 17: 5.84 – 5.93 Mb
PubMed search

Sorting nexin-9 is a protein that in humans is encoded by the SNX9 gene.^[1][2][3]

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but does contain an SH3 domain near its N-terminus. This protein interacts with the cytoplasmic domains of the precursor but not the processed forms of a disintegrin and metalloprotease domain 9 and 15. This protein binds the beta-appendage domain of adaptor protein 2 and may function to assist adaptor protein 2 in its role at the plasma membrane. This protein interacts with activated Cdc42-associated kinase-2 to regulate the degradation of epidermal growth factor receptor protein.^[3]

Interactions

SNX9 has been shown to interact with ADAM9,^[1] DNM2^[4] and ADAM15.^[1]

References

1. Howard L, Nelson KK, Maciewicz RA, Blobel CP (Dec 1999). "Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1". J Biol Chem 274 (44): 31693–9. doi:10.1074/jbc.274.44.31693. PMID 10531379.
2. Yarar D, Waterman-Storer CM, Schmid SL (Jul 2007). "SNX9 couples actin assembly to phosphoinositide signals and is required for membrane remodeling during endocytosis". Dev Cell 13 (1): 43–56. doi:10.1016/j.devcel.2007.04.014. PMID 17609109.
3. "Entrez Gene: SNX9 sorting nexin 9".
4. Lundmark, Richard; Carlsson Sven R (Nov 2003). "Sorting nexin 9 participates in clathrin-mediated endocytosis through interactions with the core components". J. Biol. Chem. (United States) 278 (47): 46772–81. doi:10.1074/jbc.M307334200. ISSN 0021-9258. PMID 12952949.

Further reading

• Teasdale RD, Loci D, Houghton F, et al. (2001). "A large family of endosome-localized proteins related to sorting nexin 1.". Biochem. J. 358 (Pt 1): 7–16. doi:10.1042/0264-6021:3580007. PMC 1222026. PMID 11485546.
• Lin Q, Lo CG, Cerione RA, Yang W (2002). "The Cdc42 target ACK2 interacts with sorting nexin 9 (SH3PX1) to regulate epidermal growth factor receptor degradation.". J. Biol. Chem. 277 (12): 10134–8. doi:10.1074/jbc.M110329200. PMID 11799118.
• Lundmark R, Carlsson SR (2002). "The beta-appendages of the four adaptor-protein (AP) complexes: structure and binding properties, and identification of sorting nexin 9 as an accessory protein to AP-2.". Biochem. J. 362 (Pt 3): 597–607. doi:10.1042/0264-6021:3620597. PMC 1222423. PMID 11879186.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Lundmark R, Carlsson SR (2004). "Sorting nexin 9 participates in clathrin-mediated endocytosis through interactions with the core components.". J. Biol. Chem. 278 (47): 46772–81. doi:10.1074/jbc.M307334200. PMID 12952949.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
• Schulze WX, Mann M (2004). "A novel proteomic screen for peptide-protein interactions.". J. Biol. Chem. 279 (11): 10756–64. doi:10.1074/jbc.M309909200. PMID 14679214.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
• Lundmark R, Carlsson SR (2004). "Regulated membrane recruitment of dynamin-2 mediated by sorting nexin 9.". J. Biol. Chem. 279 (41): 42694–702. doi:10.1074/jbc.M407430200. PMID 15299020.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Soulet F, Yarar D, Leonard M, Schmid SL (2005). "SNX9 regulates dynamin assembly and is required for efficient clathrin-mediated endocytosis.". Mol. Biol. Cell 16 (4): 2058–67. doi:10.1091/mbc.E04-11-1016. PMC 1073683. PMID 15703209.
• Yeow-Fong L, Lim L, Manser E (2005). "SNX9 as an adaptor for linking synaptojanin-1 to the Cdc42 effector ACK1.". FEBS Lett. 579 (22): 5040–8. doi:10.1016/j.febslet.2005.07.093. PMID 16137687.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Childress C, Lin Q, Yang W (2006). "Dimerization is required for SH3PX1 tyrosine phosphorylation in response to epidermal growth factor signalling and interaction with ACK2.". Biochem. J. 394 (Pt 3): 693–8. doi:10.1042/BJ20050576. PMC 1383719. PMID 16316319.
• Marchès O, Batchelor M, Shaw RK, et al. (2006). "EspF of enteropathogenic Escherichia coli binds sorting nexin 9.". J. Bacteriol. 188 (8): 3110–5. doi:10.1128/JB.188.8.3110-3115.2006. PMC 1447016. PMID 16585770.
• Schmid EM, Ford MG, Burtey A, et al. (2007). "Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly.". PLoS Biol. 4 (9): e262. doi:10.1371/journal.pbio.0040262. PMC 1540706. PMID 16903783.
• Badour K, McGavin MK, Zhang J, et al. (2007). "Interaction of the Wiskott-Aldrich syndrome protein with sorting nexin 9 is required for CD28 endocytosis and cosignaling in T cells.". Proc. Natl. Acad. Sci. U.S.A. 104 (5): 1593–8. doi:10.1073/pnas.0610543104. PMC 1785243. PMID 17242350.