SNAG1

Sorting nexin 18
Identifiers
Symbols	SNX18 ; SH3PX2; SH3PXD3B; SNAG1
External IDs	MGI: 2137642 HomoloGene: 14164 GeneCards: SNX18 Gene
Gene ontology Molecular function • protein binding • phosphatidylinositol-4,5-bisphosphate binding Cellular component • endosome • endosome membrane • cytoplasmic membrane-bounded vesicle • clathrin-coated vesicle • growth cone • cytoplasmic vesicle membrane • extrinsic component of cytoplasmic side of plasma membrane • neuronal cell body • extracellular exosome Biological process • mitotic cytokinesis • intracellular protein transport • endocytosis • mitotic nuclear division • vesicle organization • endosomal transport • cleavage furrow formation • positive regulation of GTPase activity Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	112574	170625
Ensembl	ENSG00000178996	ENSMUSG00000042364
UniProt	Q96RF0	Q91ZR2
RefSeq (mRNA)	NM_001102575	NM_130796
RefSeq (protein)	NP_001096045	NP_570614
Location (UCSC)	Chr 5: 54.52 – 54.55 Mb	Chr 13: 113.59 – 113.62 Mb
PubMed search

Sorting nexin-18 is a protein that in humans is encoded by the SNX18 gene.^[1][2][3]

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a SH3 domain. The specific function of this protein has not been determined.^[3]

References

1. Seet LF, Hong W (Sep 2006). "The Phox (PX) domain proteins and membrane traffic". Biochim Biophys Acta 1761 (8): 878–96. doi:10.1016/j.bbalip.2006.04.011. PMID 16782399.
2. Thornhill PB, Cohn JB, Drury G, Stanford WL, Bernstein A, Desbarats J (Sep 2007). "A proteomic screen reveals novel Fas ligand interacting proteins within nervous system Schwann cells". FEBS Lett 581 (23): 4455–62. doi:10.1016/j.febslet.2007.08.025. PMID 17761170.
3. "Entrez Gene: SNAG1 sorting nexin associated golgi protein 1".

Further reading

• Worby CA, Dixon JE (2003). "Sorting out the cellular functions of sorting nexins". Nat. Rev. Mol. Cell Biol. 3 (12): 919–31. doi:10.1038/nrm974. PMID 12461558.
• Xu Y, Seet LF, Hanson B, Hong W (2002). "The Phox homology (PX) domain, a new player in phosphoinositide signalling". Biochem. J. 360 (Pt 3): 513–30. doi:10.1042/0264-6021:3600513. PMC 1222253. PMID 11736640.
• Ozyildirim AM, Wistow GJ, Gao J, et al. (2005). "The lacrimal gland transcriptome is an unusually rich source of rare and poorly characterized gene transcripts". Invest. Ophthalmol. Vis. Sci. 46 (5): 1572–80. doi:10.1167/iovs.04-1380. PMID 15851553.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Schulze WX, Mann M (2004). "A novel proteomic screen for peptide-protein interactions". J. Biol. Chem. 279 (11): 10756–64. doi:10.1074/jbc.M309909200. PMID 14679214.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Teasdale RD, Loci D, Houghton F, et al. (2001). "A large family of endosome-localized proteins related to sorting nexin 1". Biochem. J. 358 (Pt 1): 7–16. doi:10.1042/0264-6021:3580007. PMC 1222026. PMID 11485546.