SNX2

Sorting nexin 2
Identifiers
Symbols	SNX2 ; TRG-9
External IDs	OMIM: 605929 MGI: 1915054 HomoloGene: 2332 GeneCards: SNX2 Gene
Gene ontology Molecular function • epidermal growth factor receptor binding • insulin receptor binding • protein binding • phosphatidylinositol binding • transferrin receptor binding • leptin receptor binding Cellular component • cytoplasm • endosome • endosome membrane • membrane • extrinsic component of membrane • lamellipodium • retromer complex • early endosome membrane • intracellular membrane-bounded organelle • protein complex • extracellular exosome Biological process • intracellular protein transport • endocytosis • vesicle organization • early endosome to Golgi transport • retrograde transport, endosome to Golgi • protein oligomerization • lamellipodium morphogenesis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6643	67804
Ensembl	ENSG00000205302	ENSMUSG00000034484
UniProt	O60749	Q9CWK8
RefSeq (mRNA)	NM_001278199	NM_026386
RefSeq (protein)	NP_001265128	NP_080662
Location (UCSC)	Chr 5: 122.77 – 122.83 Mb	Chr 18: 53.18 – 53.22 Mb
PubMed search

Sorting nexin-2 is a protein that in humans is encoded by the SNX2 gene.^[1][2]

Function

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associates with formin-binding protein 17, but its function is unknown. This protein may form oligomeric complexes with family members.^[2]

Interactions

SNX2 has been shown to interact with FNBP1.^[3][4]

References

1. Haft CR, de la Luz Sierra M, Barr VA, Haft DH, Taylor SI (Dec 1998). "Identification of a family of sorting nexin molecules and characterization of their association with receptors". Molecular and Cellular Biology 18 (12): 7278–87. doi:10.1128/mcb.18.12.7278. PMC 109309. PMID 9819414.
2. "Entrez Gene: SNX2 sorting nexin 2".
3. Fuchs U, Rehkamp GF, Slany R, Follo M, Borkhardt A (Nov 2003). "The formin-binding protein 17, FBP17, binds via a TNKS binding motif to tankyrase, a protein involved in telomere maintenance". FEBS Letters 554 (1-2): 10–6. doi:10.1016/S0014-5793(03)01063-9. PMID 14596906.
4. Fuchs U, Rehkamp G, Haas OA, Slany R, Kōnig M, Bojesen S, Bohle RM, Damm-Welk C, Ludwig WD, Harbott J, Borkhardt A (Jul 2001). "The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia". Proceedings of the National Academy of Sciences of the United States of America 98 (15): 8756–61. doi:10.1073/pnas.121433898. PMC 37508. PMID 11438682.

Further reading

• Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Haft CR, de la Luz Sierra M, Bafford R, Lesniak MA, Barr VA, Taylor SI (Dec 2000). "Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes". Molecular Biology of the Cell 11 (12): 4105–16. doi:10.1091/mbc.11.12.4105. PMC 15060. PMID 11102511.
• Parks WT, Frank DB, Huff C, Renfrew Haft C, Martin J, Meng X, de Caestecker MP, McNally JG, Reddi A, Taylor SI, Roberts AB, Wang T, Lechleider RJ (Jun 2001). "Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases". The Journal of Biological Chemistry 276 (22): 19332–9. doi:10.1074/jbc.M100606200. PMID 11279102.
• Fuchs U, Rehkamp G, Haas OA, Slany R, Kōnig M, Bojesen S, Bohle RM, Damm-Welk C, Ludwig WD, Harbott J, Borkhardt A (Jul 2001). "The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia". Proceedings of the National Academy of Sciences of the United States of America 98 (15): 8756–61. doi:10.1073/pnas.121433898. PMC 37508. PMID 11438682.
• Teasdale RD, Loci D, Houghton F, Karlsson L, Gleeson PA (Aug 2001). "A large family of endosome-localized proteins related to sorting nexin 1". The Biochemical Journal 358 (Pt 1): 7–16. doi:10.1042/0264-6021:3580007. PMC 1222026. PMID 11485546.
• Fuchs U, Rehkamp GF, Slany R, Follo M, Borkhardt A (Nov 2003). "The formin-binding protein 17, FBP17, binds via a TNKS binding motif to tankyrase, a protein involved in telomere maintenance". FEBS Letters 554 (1-2): 10–6. doi:10.1016/S0014-5793(03)01063-9. PMID 14596906.
• Gullapalli A, Garrett TA, Paing MM, Griffin CT, Yang Y, Trejo J (May 2004). "A role for sorting nexin 2 in epidermal growth factor receptor down-regulation: evidence for distinct functions of sorting nexin 1 and 2 in protein trafficking". Molecular Biology of the Cell 15 (5): 2143–55. doi:10.1091/mbc.E03-09-0711. PMC 404011. PMID 14978220.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Schaaf CP, Benzing J, Schmitt T, Erz DH, Tewes M, Bartram CR, Janssen JW (Feb 2005). "Novel interaction partners of the TPR/MET tyrosine kinase". FASEB Journal 19 (2): 267–9. doi:10.1096/fj.04-1558fje. PMID 15546961.
• Abdul-Ghani M, Hartman KL, Ngsee JK (Jul 2005). "Abstrakt interacts with and regulates the expression of sorting nexin-2". Journal of Cellular Physiology 204 (1): 210–8. doi:10.1002/jcp.20285. PMC 2963638. PMID 15690390.
• Carlton JG, Bujny MV, Peter BJ, Oorschot VM, Rutherford A, Arkell RS, Klumperman J, McMahon HT, Cullen PJ (Oct 2005). "Sorting nexin-2 is associated with tubular elements of the early endosome, but is not essential for retromer-mediated endosome-to-TGN transport". Journal of Cell Science 118 (Pt 19): 4527–39. doi:10.1242/jcs.02568. PMC 1904489. PMID 16179610.
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (Oct 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
• Rojas R, Kametaka S, Haft CR, Bonifacino JS (Feb 2007). "Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors". Molecular and Cellular Biology 27 (3): 1112–24. doi:10.1128/MCB.00156-06. PMC 1800681. PMID 17101778.
• Skånland SS, Wälchli S, Utskarpen A, Wandinger-Ness A, Sandvig K (Mar 2007). "Phosphoinositide-regulated retrograde transport of ricin: crosstalk between hVps34 and sorting nexins". Traffic 8 (3): 297–309. doi:10.1111/j.1600-0854.2006.00527.x. PMID 17319803.