Beta-peptidyl aminopeptidase

Beta-peptidyl aminopeptidase
Identifiers
EC number	3.4.11.25
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Beta-peptidyl aminopeptidase (EC 3.4.11.25, BapA) is an enzyme.^[1][2][3][4] This enzyme catalyses the following chemical reaction

Cleaves N-terminal beta-homoamino acids from peptides composed of 2 to 6 amino acids

Sphingosinicella xenopeptidilytica strain 3-2W4 could use beta-peptides beta-homoVal-beta-homoAla-beta-homoLeu and beta-homoAla-beta-homoLeu as only source of carbon and energy.

References

1. Heck, T., Limbach, M., Geueke, B., Zacharias, M., Gardiner, J., Kohler, H.P. and Seebach, D. (2006). "Enzymatic degradation of β- and mixed α,β-oligopeptides". Chem. Biodivers. 3: 1325–1348. doi:10.1002/cbdv.200690136. PMID 17193247.
2. Geueke, B., Namoto, K., Seebach, D. and Kohler, H.P. (2005). "A novel β-peptidyl aminopeptidase (BapA) from strain 3-2W4 cleaves peptide bonds of synthetic β-tri- and β-dipeptides". J. Bacteriol. 187: 5910–5917. doi:10.1128/jb.187.17.5910-5917.2005. PMID 16109932.
3. Geueke, B., Heck, T., Limbach, M., Nesatyy, V., Seebach, D. and Kohler, H.P. (2006). "Bacterial β-peptidyl aminopeptidases with unique substrate specificities for β-oligopeptides and mixed β,α-oligopeptides". FEBS J. 273: 5261–5272. doi:10.1111/j.1742-4658.2006.05519.x. PMID 17064315.
4. Heck, T., Kohler, H.P., Limbach, M., Flögel, O., Seebach, D. and Geueke, B. (2007). "Enzyme-catalyzed formation of β-peptides: β-peptidyl aminopeptidases BapA and DmpA acting as β-peptide-synthesizing enzymes". Chem. Biodivers. 4: 2016–1030. doi:10.1002/cbdv.200790168. PMID 17886858.

External links

• Beta-peptidyl aminopeptidase at the US National Library of Medicine Medical Subject Headings (MeSH)