CP-94253

CP-94253

Systematic (IUPAC) name
3-(1,2,5,6-tetrahydro-4-pyridyl)-5-propoxypyrrolo[3,2-b]pyridine
Identifiers
CAS Number	131084-35-0
PubChem	CID 4029677
IUPHAR/BPS	3221
ChemSpider	3246572
Chemical data
Formula	C15H19N3O
Molar mass	257.330 g/mol
SMILES c13nc(OCCC)ccc1ncc3C2=CCNCC2
InChI InChI=1S/C15H19N3O/c1-2-9-19-14-4-3-13-15(18-14)12(10-17-13)11-5-7-16-8-6-11/h3-5,10,16-17H,2,6-9H2,1H3 Key:KWQWBZIGHIOKIO-UHFFFAOYSA-N
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CP-94253 is a drug which acts as a potent and selective serotonin 5-HT_1B receptor agonist, with approximately 25x and 40x selectivity over the closely related 5-HT_1D and 5-HT_1A receptors.^[1] It has a range of behavioural effects in animal studies, including promoting wakefulness by increasing dopamine release in the brain,^[2][3] reducing food intake and promoting satiety,^[4][5][6] enhancing the reinforcing effects of cocaine,^{[7][8][9][10]} and possible antidepressant effects.^[11]

References

1. Koe KB, Nielsen JA, Macor JE, Heym J. Biochemical and behavioral studies of the 5-HT1B receptor agonist, CP-94,253. Drug Development Research. 1992;26(3):241-250. doi:10.1002/ddr.430260305
2. Monti JM, Monti D, Jantos H, Ponzoni A. Effects of selective activation of the 5-HT1B receptor with CP-94,253 on sleep and wakefulness in the rat. Neuropharmacology. 1995 Dec;34(12):1647-51. PMID 8788962
3. Iyer RN, Bradberry CW. Serotonin-mediated increase in prefrontal cortex dopamine release: pharmacological characterization. Journal of Pharmacology and Experimental Therapeutics. 1996 Apr;277(1):40-7. PMID 8613947
4. Halford JC, Blundell JE. The 5-HT1B receptor agonist CP-94,253 reduces food intake and preserves the behavioural satiety sequence. Physiology and Behaviour. 1996 Sep;60(3):933-9. PMID 8873272
5. Lee MD, Simansky KJ. CP-94,253: a selective serotonin1B (5-HT1B) agonist that promotes satiety. Psychopharmacology (Berlin). 1997 Jun;131(3):264-70. PMID 9203237
6. Lee MD, Kennett GA, Dourish CT, Clifton PG. 5-HT1B receptors modulate components of satiety in the rat: behavioural and pharmacological analyses of the selective serotonin1B agonist CP-94,253. Psychopharmacology (Berlin). 2002 Oct;164(1):49-60. PMID 12373419
7. Parsons LH, Weiss F, Koob GF. Serotonin1B receptor stimulation enhances cocaine reinforcement. Journal of Neuroscience. 1998 Dec 1;18(23):10078-89. PMID 9822762
8. Przegalinski E, Filip M, Papla I, Siwanowicz J. Effect of serotonin (5-HT)1B receptor ligands on cocaine sensitization in rats. Behavioural Pharmacology. 2001 Apr;12(2):109-16. PMID 11396515
9. Przegaliński E, Gołda A, Frankowska M, Zaniewska M, Filip M (March 2007). "Effects of serotonin 5-HT1B receptor ligands on the cocaine- and food-maintained self-administration in rats". European Journal of Pharmacology 559 (2-3): 165–72. doi:10.1016/j.ejphar.2006.12.012. PMID 17291490.
10. Przegaliński E, Gołda A, Filip M (2008). "Effects of serotonin (5-HT)(1B) receptor ligands on cocaine-seeking behavior in rats". Pharmacological Reports : PR 60 (6): 798–810. PMID 19211971.
11. Tatarczyńska E, Antkiewicz-Michaluk L, Kłodzińska A, Stachowicz K, Chojnacka-Wójcik E. Antidepressant-like effect of the selective 5-HT1B receptor agonist CP 94253: a possible mechanism of action. European Journal of Pharmacology. 2005 May 23;516(1):46-50. PMID 15913599