CPA superfamily

The CPA Superfamily is a group of transport proteins named after one of its constituent members, the monovalent cation:proton antiporter-2 (CPA2; TC# 2.A.37). According to a phylogenetic tree produced using proteins in TCDB and Clustal X, published by Chen et. al. (2010) it appears as though CPA1 used to also be a member of the CPA superfamily, until enough evidence was gathered to delegated it to the VIC superfamily.[1][2][3] As of April 2016, the CPA superfamily consists of four members:

Structural variation exists between families. For example, members of the CPA2 family are between 300 and 900 amino acyl residues (aas) in length and exhibit 10 to 14 transmembrane segments (TMSs), while members of the MSS family are shorter than 300 aas and exhibit 4 to 7 TMSs.

See also

Further reading

References

  1. ↑ Chen, Jonathan S.; Reddy, Vamsee; Chen, Joshua H.; Shlykov, Maksim A.; Zheng, Wei Hao; Cho, Jaehoon; Yen, Ming Ren; Saier, Milton H.; Jr. "Phylogenetic Characterization of Transport Protein Superfamilies: Superiority of SuperfamilyTree Programs over Those Based on Multiple Alignments". Journal of Molecular Microbiology and Biotechnology 21 (3-4): 83–96. doi:10.1159/000334611. PMC: 3290041. PMID 22286036.
  2. ↑ Koishi, Ryuta; Xu, Haoxing; Ren, Dejian; Navarro, Betsy; Spiller, Benjamin W.; Shi, Qing; Clapham, David E. (2004-03-05). "A superfamily of voltage-gated sodium channels in bacteria". The Journal of Biological Chemistry 279 (10): 9532–9538. doi:10.1074/jbc.M313100200. ISSN 0021-9258. PMID 14665618.
  3. ↑ "1.A.1 The Voltage-gated Ion Channel (VIC) Superfamily". TCDB. Retrieved 2016-04-05.

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