Malonate:Sodium symporter

The Malonate:Na+ Symporter (MSS) Family (TC# 2.A.70) is a group of transport proteins belonging to the CPA superfamily. These proteins are composites with constituents ranging in size from 129 to 255 amino acyl residues (aas) and exhibiting 4 to 7 transmembrane segments (TMSs). A representative list of proteins belonging to the MSS family can be found in the Transporter Classification Database.[1]

MadLM

One constituent member of the MSS family, the monobasic malonate:Na+ symporter of Malonomonas rubra, has been functionally and genetically characterized. It consists of two integral membrane proteins, MadL (129 aas; accession number O06931) and MadM (255 aas; accession number O06932) which exhibit 4 and 7 putative transmembrane spanners, respectively. The transporter is believed to catalyze the electroneutral reversible uptake of H+-malonate with one Na+, and both subunits have been shown to be essential for activity. There is a close two-subunit homologue in Pseudomonas putida, which is encoded within the malonate decarboxylase gene cluster of this organism.[2] The NapA Na+/H+ antiporter of Enterococcus hirae (CPA2 family; TC #2.A.37) also appears to be distantly related to MadM.[1]

The transport reaction catalyzed by MadLM is:

H+ malonate (out) + Na+ (out) ⇌ H+ malonate (in) + Na+ (in).

See also

Further reading

References

  1. 1 2 "2.A.70 The Malonate:Na+ Symporter (MSS) Family". TCDB. Retrieved 2016-04-06.
  2. ↑ Chohnan, S.; Kurusu, Y.; Nishihara, H.; Takamura, Y. (1999-05-15). "Cloning and characterization of mdc genes encoding malonate decarboxylase from Pseudomonas putida". FEMS microbiology letters 174 (2): 311–319. ISSN 0378-1097. PMID 10339824.

As of this edit, this article uses content from "2.A.70 The Malonate:Na+ Symporter (MSS) Family", which is licensed in a way that permits reuse under the Creative Commons Attribution-ShareAlike 3.0 Unported License, but not under the GFDL. All relevant terms must be followed.

This article is issued from Wikipedia - version of the Thursday, April 07, 2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.