X-His dipeptidase

Xaa-His dipeptidase (EC 3.4.13.3, aminoacylhistidine dipeptidase, carnosinase, homocarnosinase, dipeptidase M) is an enzyme.^[1]^[2]^[3]^[4] This enzyme catalyses the following chemical reaction

Hydrolysis of Xaa!His dipeptides

This mammalian cytosolic enzyme also acts on anserine and homocarnosine.

References

↑ Hanson, H.T. and Smith, E.L. (1949). "Carnosinase: an enzyme of swine kidney". J. Biol. Chem. 179: 789–801.
↑ Rosenberg, A. (1960). "The activation of carnosinase by divalent ions". Biochim. Biophys. Acta 45: 297–316. doi:10.1016/0006-3002(60)91454-2. PMID 13743376.
↑ Lenney, J.F., Kan, S.C., Siu, K. and Sugiyama, G.H. (1977). "Homocarnosinase: a hog kidney dipeptidase with a broader specificity than carnosinase". Arch. Biochem. Biophys. 184 (1): 257–266. doi:10.1016/0003-9861(77)90349-6. PMID 21630.
↑ Lenney, J.F. (1990). "Separation and characterization of 2 carnosine-splitting cytosolic dipeptidases from hog kidney (carnosinase and nonspecific dipeptidase)". Biol. Chem. Hoppe-Seyler 371: 433–440. doi:10.1515/bchm3.1990.371.1.433. PMID 2378680.

External links

Xaa-His dipeptidase at the US National Library of Medicine Medical Subject Headings (MeSH)

Hydrolase: proteases (EC 3.4)

3.4.11-19: Exopeptidase

3.4.11	Aminopeptidase Alanine Arginyl Aspartyl Cystinyl Leucyl Glutamyl Methionyl 1 2 O

3.4.13	Dipeptidase 1 2 3

3.4.14	Dipeptidyl peptidase Cathepsin C Dipeptidyl peptidase-4 Tripeptidyl peptidase Tripeptidyl peptidase I Tripeptidyl peptidase II

3.4.15	Angiotensin-converting enzyme

3.4.16	Serine type carboxypeptidases: Cathepsin A DD-transpeptidase

3.4.17	Metalloexopeptidases Carboxypeptidase A A2 B C E Glutamate II

Other/ungrouped	Metalloexopeptidase

3.4.21-25: Endopeptidase

Other/ungrouped: Amyloid precursor protein secretase

3.4.99: Unknown

Staphylokinase

Proteins: enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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