Casticin

Casticin

Names
IUPAC name 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,6,7-trimethoxychromen-4-one
Other names Vitexicarpin
Identifiers
CAS Number	479-91-4
ChEBI	CHEBI:69355
ChEMBL	ChEMBL452767
ChemSpider	4474632
Jmol interactive 3D	Image
PubChem	5315263
InChI InChI=1S/C19H18O8/c1-23-11-6-5-9(7-10(11)20)17-19(26-4)16(22)14-12(27-17)8-13(24-2)18(25-3)15(14)21/h5-8,20-21H,1-4H3 Key: PJQLSMYMOKWUJG-UHFFFAOYSA-N InChI=1/C19H18O8/c1-23-11-6-5-9(7-10(11)20)17-19(26-4)16(22)14-12(27-17)8-13(24-2)18(25-3)15(14)21/h5-8,20-21H,1-4H3 Key: PJQLSMYMOKWUJG-UHFFFAOYAH
SMILES COC1=C(C=C(C=C1)C2=C(C(=O)C3=C(C(=C(C=C3O2)OC)OC)O)OC)O
Properties
Chemical formula	C19H18O8
Molar mass	374.34 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Casticin is a methyoxylated flavonol, meaning the core flavonoid structure has methyl groups attached. Found in Artemisia annua, the flavonoid has been shown to enhance the antimalarial activity of artemisinin though casticin itself has no direct antimalarial effects.^[1][2] It has been shown to have anti-mitotic activity. It is also found in Vitex agnus-castus.^[3]

References

1. Elford BC; Roberts MF; Phillipson JD; Wilson RJ (1987). "Potentiation of the antimalarial activity of qinghaosu by methoxylated flavones". Trans R Soc Trop Med Hyg 81 (3): 434–436. doi:10.1016/0035-9203(87)90161-1. PMID 3318019.
2. Liu KC; Yang SL; Roberts MF; Elford BC; Phillipson JD (1992). "Antimalarial activity of Artemisia annua flavonoids from whole plants and cell cultures". Plant Cell Rep 11 (12): 537–640. doi:10.1007/bf00236389. PMID 24213368.
3. Hoberg, Eva; Meier, Beat; Sticher, Otto (2000). "An analytical high performance liquid chromatographic method for the determination of agnuside and p-hydroxybenzoic acid contents in Agni-casti fructus". Phytochemical Analysis 11 (5): 327–329. doi:10.1002/1099-1565(200009/10)11:5<327::AID-PCA523>3.0.CO;2-0.

External links

• "Casticin induces human glioma cell death through apoptosis and mitotic arrest". Cell. Physiol. Biochem. 31: 805–14. 2013. doi:10.1159/000350098. PMID 23816816.