Cathepsin H

Cathepsin H
PDB rendering based on 1nb3.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1BZN​
Identifiers
Symbols	CTSH ; ACC-4; ACC-5; ACC4; ACC5; CPSB; minichain
External IDs	OMIM: 116820 MGI: 107285 HomoloGene: 36159 ChEMBL: 2225 GeneCards: CTSH Gene
EC number	3.4.22.16
Gene ontology Molecular function • endopeptidase activity • aminopeptidase activity • cysteine-type endopeptidase activity • serine-type endopeptidase activity • protein binding • peptidase activity • cysteine-type peptidase activity • cysteine-type endopeptidase activator activity involved in apoptotic process • HLA-A specific activating MHC class I receptor activity • thyroid hormone binding Cellular component • extracellular space • lysosome • cytosol • extracellular exosome • alveolar lamellar body Biological process • metanephros development • T cell mediated cytotoxicity • adaptive immune response • immune response-regulating signaling pathway • proteolysis • activation of cysteine-type endopeptidase activity involved in apoptotic process • positive regulation of cell proliferation • positive regulation of gene expression • positive regulation of epithelial cell migration • neuropeptide catabolic process • bradykinin catabolic process • positive regulation of peptidase activity • antigen processing and presentation • positive regulation of cell migration • zymogen activation • protein destabilization • response to retinoic acid • membrane protein proteolysis • negative regulation of apoptotic process • surfactant homeostasis • positive regulation of angiogenesis • proteolysis involved in cellular protein catabolic process • dichotomous subdivision of terminal units involved in lung branching • ERK1 and ERK2 cascade • cellular response to thyroid hormone stimulus • positive regulation of apoptotic signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1512	13036
Ensembl	ENSG00000103811	ENSMUSG00000032359
UniProt	P09668	P49935
RefSeq (mRNA)	NM_004390	NM_007801
RefSeq (protein)	NP_004381	NP_031827
Location (UCSC)	Chr 15: 78.92 – 78.95 Mb	Chr 9: 90.05 – 90.08 Mb
PubMed search

Cathepsin H is a protein that in humans is encoded by the CTSH gene.^[1][2]

The protein encoded by this gene is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors. Two transcript variants encoding different isoforms have been found for this gene.^[2]

References

1. Fuchs R, Machleidt W, Gassen HG (Feb 1989). "Molecular cloning and sequencing of a cDNA coding for mature human kidney cathepsin H". Biol Chem Hoppe Seyler 369 (6): 469–75. doi:10.1515/bchm3.1988.369.1.469. PMID 2849458.
2. "Entrez Gene: CTSH cathepsin H".

Further reading

• Sawicki G, Warwas M (1990). "Cathepsin H from human placenta.". Acta Biochim. Pol. 36 (3-4): 343–51. PMID 2486008.
• Fuchs R, Gassen HG (1990). "Nucleotide sequence of human preprocathepsin H, a lysosomal cysteine proteinase.". Nucleic Acids Res. 17 (22): 9471. doi:10.1093/nar/17.22.9471. PMC 335148. PMID 2587265.
• Chernaia VI, Reva AD (1990). "[Cathepsin H activity in the human brain and human brain neoplasms]". Ukr. Biokhim. Zh. 61 (5): 47–50. PMID 2588347.
• Ritonja A, Popović T, Kotnik M; et al. (1988). "Amino acid sequences of the human kidney cathepsins H and L.". FEBS Lett. 228 (2): 341–5. doi:10.1016/0014-5793(88)80028-0. PMID 3342889.
• Järvinen M, Rinne A (1983). "Human spleen cysteineproteinase inhibitor. Purification, fractionation into isoelectric variants and some properties of the variants.". Biochim. Biophys. Acta 708 (2): 210–7. doi:10.1016/0167-4838(82)90222-9. PMID 6184075.
• Kato S, Sekine S, Oh SW; et al. (1995). "Construction of a human full-length cDNA bank.". Gene 150 (2): 243–50. doi:10.1016/0378-1119(94)90433-2. PMID 7821789.
• Baumgrass R, Williamson MK, Price PA (1997). "Identification of peptide fragments generated by digestion of bovine and human osteocalcin with the lysosomal proteinases cathepsin B, D, L, H, and S.". J. Bone Miner. Res. 12 (3): 447–55. doi:10.1359/jbmr.1997.12.3.447. PMID 9076588.
• Söderström M, Salminen H, Glumoff V; et al. (1999). "Cathepsin expression during skeletal development.". Biochim. Biophys. Acta 1446 (1-2): 35–46. doi:10.1016/S0167-4781(99)00068-8. PMID 10395917.
• Jokimaa V, Oksjoki S, Kujari H; et al. (2001). "Expression patterns of cathepsins B, H, K, L and S in the human endometrium.". Mol. Hum. Reprod. 7 (1): 73–8. doi:10.1093/molehr/7.1.73. PMID 11134363.
• Uusitalo H, Hiltunen A, Söderström M; et al. (2001). "Expression of cathepsins B, H, K, L, and S and matrix metalloproteinases 9 and 13 during chondrocyte hypertrophy and endochondral ossification in mouse fracture callus.". Calcif. Tissue Int. 67 (5): 382–90. doi:10.1007/s002230001152. PMID 11136537.
• Pol E, Björk I (2001). "Role of the single cysteine residue, Cys 3, of human and bovine cystatin B (stefin B) in the inhibition of cysteine proteinases.". Protein Sci. 10 (9): 1729–38. doi:10.1110/ps.11901. PMC 2253190. PMID 11514663.
• Waghray A, Keppler D, Sloane BF; et al. (2002). "Analysis of a truncated form of cathepsin H in human prostate tumor cells.". J. Biol. Chem. 277 (13): 11533–8. doi:10.1074/jbc.M109557200. PMID 11796715.
• Brasch F, Ten Brinke A, Johnen G; et al. (2002). "Involvement of cathepsin H in the processing of the hydrophobic surfactant-associated protein C in type II pneumocytes.". Am. J. Respir. Cell Mol. Biol. 26 (6): 659–70. doi:10.1165/ajrcmb.26.6.4744. PMID 12034564.
• Bühling F, Waldburg N, Krüger S; et al. (2003). "Expression of cathepsins B, H, K, L, and S during human fetal lung development.". Dev. Dyn. 225 (1): 14–21. doi:10.1002/dvdy.10134. PMID 12203716.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Jenko S, Dolenc I, Guncar G; et al. (2003). "Crystal structure of Stefin A in complex with cathepsin H: N-terminal residues of inhibitors can adapt to the active sites of endo- and exopeptidases.". J. Mol. Biol. 326 (3): 875–85. doi:10.1016/S0022-2836(02)01432-8. PMID 12581647.
• Nagai A, Terashima M, Harada T; et al. (2003). "Cathepsin B and H activities and cystatin C concentrations in cerebrospinal fluid from patients with leptomeningeal metastasis.". Clin. Chim. Acta 329 (1-2): 53–60. doi:10.1016/S0009-8981(03)00023-8. PMID 12589965.
• Han SR, Momeni A, Strach K; et al. (2004). "Enzymatically modified LDL induces cathepsin H in human monocytes: potential relevance in early atherogenesis.". Arterioscler. Thromb. Vasc. Biol. 23 (4): 661–7. doi:10.1161/01.ATV.0000063614.21233.BF. PMID 12615673.
• Dodt J, Reichwein J (2004). "Human cathepsin H: deletion of the mini-chain switches substrate specificity from aminopeptidase to endopeptidase.". Biol. Chem. 384 (9): 1327–32. doi:10.1515/BC.2003.149. PMID 14515996.

External links

• The MEROPS online database for peptidases and their inhibitors: C01.040