Actinidain

actinidain

Biological assembly image of actinidain from Actinidia chinensis. From PDB: 1AEC.
Identifiers
EC number 3.4.22.14
CAS number 39279-27-1
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

Actinidain (EC 3.4.22.14, actinidin, Actinidia anionic protease, proteinase A2 of Actinidia chinensis) is a type of cysteine protease enzyme found in fruits including kiwifruit (genus Actinidia), pineapple, mango, banana and papaya. This enzyme is part of the papain-like peptidase C1 family.[1][2][3] This enzyme catalyses the following chemical reaction similar to that of papain.

From the kiwi fruit or Chinese gooseberry (Actinidia chinensis).

It is a known allergen and commercially useful as a meat tenderizer.

References

  1. Baker, E.N., Boland, M.J., Calder, P.C. and Hardman, M.J. (1980). "The specificity of actinidin and its relationship to the structure of the enzyme". Biochim. Biophys. Acta 616: 30–34. doi:10.1016/0005-2744(80)90260-0. PMID 7002215.
  2. Kamphuis, I.G., Drenth, J. and Baker, E.N. (1985). "Thiol proteases. Comparative studies based on the high-resolution structures of papain and actinidin, and on amino acid sequence information for cathepsins B and H, and stem bromelain". J. Mol. Biol. 182: 317–329. doi:10.1016/0022-2836(85)90348-1. PMID 3889350.
  3. Baker, E.N. and Drenth, J. (1987). "The thiol proteases: structure and mechanism". In Jurnak, F.A. and McPherson, A. Active Sites of Enzymes. Biological Macromolecules and Assemblies 3. New York: John Wiley and Sons. pp. 314–368. ISBN 0-471-85142-6.

External links

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