Clofedanol

Clofedanol

Systematic (IUPAC) name
1-(2-chlorophenyl)-3-dimethylamino- 1-phenyl-propan-1-ol
Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Routes of administration	Oral
Identifiers
CAS Number	791-35-5
ATC code	R05DB10 (WHO)
PubChem	CID 2795
IUPHAR/BPS	7324
DrugBank	DB04837
ChemSpider	2693
UNII	42C50P12AP
KEGG	D07721
ChEMBL	CHEMBL1201313
Chemical data
Formula	C17H20ClNO
Molar mass	289.8 g/mol
SMILES Clc1ccccc1C(O)(c2ccccc2)CCN(C)C
InChI InChI=1S/C17H20ClNO/c1-19(2)13-12-17(20,14-8-4-3-5-9-14)15-10-6-7-11-16(15)18/h3-11,20H,12-13H2,1-2H3 Key:WRCHFMBCVFFYEQ-UHFFFAOYSA-N
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Clofedanol (INN) or chlophedianol (BAN) is a centrally acting cough suppressant used in the treatment of dry cough. Clofedanol has local anesthetic and antihistamine properties, and may have anticholinergic effects at high doses.^[1] It is marketed in Canada under the trade name Ulone, but is not available currently in the United States. In August 2009, Centrix Pharmaceutical announced the launch of a cough syrup containing a mixture of clophedianol and pseudoephedrine, marketed under the brand name Clofera. It has a release to market date in the beginning of the fourth quarter 2009.^[2] Chlophedianol was approved for OTC status in 1987 by the FDA OTC monograph process^[3] and its safety and efficacy data are limited.

Synthesis

Clofedanol synthesis: R. Lorenz and H. Henecka, U.S. Patent 3,031,377 (1962).

See also

• Azacyclonol

References

1. "Clofedanol" (in French). BIAM. 1998-07-24. Retrieved 2007-04-15.
2. "Centrix Pharmaceutical Announces Clofera(TM), a Unique Antitussive and Nasal Decongestant for the Temporary Relief of Cough and Nasal Congestion". Cenrx.com. Retrieved 2009-09-27.
3. "Department of Health and Human Services. Food and Drug Administration. 21 CFR Parts 310, 341, and 369. Docket No. 76N-052T. Cold, cough, allergy, bronchodilator, and antiasthmatic drug products for over-the0counter human use; final monograph for OTC antitussive drug products. Federal Register 1987;52(155):30042-57" (PDF). FDA.gov. 1987-08-12.