| Office | Name | Date | Notes |
Prime Minister, First Lord of the Treasury and Leader of the House of Lords | The Earl of Derby | 21 February 1858 – 11 June 1859 | |
Chancellor of the Exchequer and Leader of the House of Commons | Benjamin Disraeli | 26 February 1858 | |
| Parliamentary Secretary to the Treasury | Sir William Jolliffe, Bt | 2 March 1858 | |
| Financial Secretary to the Treasury | George Alexander Hamilton | 2 March 1858 | |
| Sir Stafford Northcote | 21 January 1859 |
| Junior Lords of the Treasury | Lord Henry Gordon-Lennox | 1 March 1858 – 14 March 1859 | |
| Thomas Edward Taylor | 1 March 1858 – 11 June 1859 |
| Henry Whitmore | 1 March 1858 – 11 June 1859 |
| Peter Blackburn | 15 March 1859 – 11 June 1859 |
| Lord Chancellor | The Lord Chelmsford | 26 February 1858 | |
| Lord President of the Council | The Marquess of Salisbury | 26 February 1858 | |
| Lord Privy Seal | The Earl of Hardwicke | 26 February 1858 | |
| Secretary of State for the Home Department | Spencer Walpole | 26 February 1858 | |
| T. H. S. Sotheron Estcourt | 3 March 1859 |
| Under-Secretary of State for the Home Department | Gathorne Hardy | 26 February 1858 | |
| Secretary of State for Foreign Affairs | The Earl of Malmesbury | 26 February 1858 | |
| Parliamentary Under-Secretary of State for Foreign Affairs | William Vesey Fitzgerald | 26 February 1858 | |
| Secretary of State for War | Jonathan Peel | 26 February 1858 | |
| Under-Secretary of State for War | The Viscount Hardinge | 8 March 1858 | |
| The Earl of Rosslyn | 3 March 1859 |
| Surveyor-General of the Ordnance | vacant | — | |
| Secretary of State for the Colonies | Lord Stanley | 26 February 1858 | |
| Sir Edward Bulwer-Lytton | 5 June 1858 |
| Under-Secretary of State for the Colonies | The Earl of Carnarvon | 26 February 1858 | |
| Secretary of State for India | Lord Stanley | 2 September 1858 | |
| Under-Secretary of State for India | Henry James Baillie | 30 September 1858 | |
| First Lord of the Admiralty | Sir John Pakington | 8 March 1858 | |
| First Secretary of the Admiralty | Henry Thomas Lowry Corry | 9 March 1858 | |
| Civil Lord of the Admiralty | Lord Lovaine | 8 March 1858 | |
| Frederick Lygon | 9 March 1859 |
| President of the Board of Control | The Earl of Ellenborough | 6 March 1858 | Board of Control abolished 2 August 1858 |
| Lord Stanley | 5 June 1858 |
| Joint Secretary to the Board of Control | Henry James Baillie | 6 March 1858 |
| President of the Board of Trade | Joseph Warner Henley | 26 February 1858 | |
| The Earl of Donoughmore | 3 March 1859 |
| Vice-President of the Board of Trade | The Earl of Donoughmore | 6 April 1858 | |
| Lord Lovaine | 3 March 1859 |
| First Commissioner of Works | Lord John Manners | 26 February 1858 | |
| Vice-President of the Committee on Education | Charles Bowyer Adderley | 12 March 1858 | |
| President of the Board of Health | Charles Bowyer Adderley | 8 March 1858 | office abolished 1858 |
| Chief Secretary for Ireland | Lord Naas | 4 March 1858 | |
| Lord Lieutenant of Ireland | The Earl of Eglinton | 8 March 1858 | |
| Chancellor of the Duchy of Lancaster | The Duke of Montrose | 26 February 1858 | |
| Paymaster-General | The Earl of Donoughmore | 6 April 1858 | |
| Lord Lovaine | 3 March 1859 |
| President of the Poor Law Board | T.H.S. Sotheron Estcourt | 6 March 1858 | |
| Earl of March | 7 March 1859 |
| Parliamentary Secretary to the Poor Law Board | Frederick Winn Knight | 12 March 1858 | |
| Postmaster-General | The Lord Colchester | 13 March 1858 | |
| Attorney General | Sir Fitzroy Kelly | 26 February 1858 | |
| Solicitor General | Sir Hugh Cairns | 26 February 1858 | |
| Judge Advocate General | John Mowbray | 13 March 1858 | |
| Lord Advocate | John Inglis | 1 March 1858 | |
| Charles Baillie | 10 July 1858 |
| David Mure | 15 April 1859 |
| Solicitor General for Scotland | Charles Baillie | 17 March 1858 | |
| David Mure | 12 July 1858 |
| George Patton | 3 May 1859 |
| Attorney General for Ireland | James Whiteside | February 1858 | |
| Solicitor General for Ireland | Henry George Hughes | February 1858 | |
| Edmund Hayes | 1859 |
| Lord Steward of the Household | The Marquess of Exeter | 26 February 1858 | |
| Lord Chamberlain of the Household | The Earl De La Warr | 26 February 1858 | |
| Master of the Horse | The Duke of Beaufort | 26 February 1858 | |
| Treasurer of the Household | Lord Claud Hamilton | 26 February 1858 | |
| Comptroller of the Household | George Weld-Forester | 26 February 1858 | |
| Captain of the Gentlemen-at-Arms | The Earl Talbot | 26 February 1858 | |
| Captain of the Yeomen of the Guard | The Lord de Ros | 17 March 1858 | |
| Master of the Buckhounds | The Earl of Sandwich | 26 February 1858 | |
| Chief Equerry and Clerk Marshal | The Lord Colville of Culross | 26 February 1858 | |
| Mistress of the Robes | The Duchess of Manchester | 26 February 1858 | |
| Lords in Waiting | The Earl of Verulam | 26 February 1858 – 11 June 1859 | |
| The Earl of Sheffield | 26 February 1858 – 11 June 1859 |
| The Viscount Strathallan | 26 February 1858 – 11 June 1859 |
| The Lord Polwarth | 26 February 1858 – 11 June 1859 |
| The Lord Crofton | 26 February 1858 – 11 June 1859 |
| The Lord Bateman | 26 February 1858 – 11 June 1859 |
| The Lord Raglan | 26 February 1858 – 11 June 1859 |