| Office | Name | Date | Notes |
Prime Minister, First Lord of the Treasury and Leader of the House of Commons | William Ewart Gladstone | 3 December 1868 – 17 February 1874 | the Government resigned 13 March 1873 and resumed 19 March 1873 |
| Chancellor of the Exchequer | Robert Lowe | 9 December 1868 | |
| William Ewart Gladstone | 11 August 1873 |
| Parliamentary Secretary to the Treasury | George Glyn | 9 December 1868 | |
| Arthur Peel | 1 August 1873 |
| Financial Secretary to the Treasury | Acton Smee Ayrton | 9 December 1868 | |
| James Stansfeld | 2 November 1869 |
| William Edward Baxter | 17 March 1871 |
| John George Dodson | 11 August 1873 |
| Junior Lords of the Treasury | James Stansfeld | 16 December 1868 – 2 November 1869 | |
| The Marquess of Lansdowne | 16 December 1868 – 25 April 1872 |
| William Patrick Adam | 16 December 1868 – 8 August 1873 |
| John Cranch Walker Vivian | 16 December 1868 – 4 August 1870 |
| William Henry Gladstone | 2 November 1869 – 17 February 1874 |
| Lord Frederick Cavendish | 8 August 1873 – 17 February 1874 |
| Algernon Greville | 8 August 1873 – 17 February 1874 |
| Lord Chancellor | The Lord Hatherley | 9 December 1868 | |
| The Lord Selborne | 15 October 1872 |
| Lord President of the Council | The Earl de Grey and Ripon | 9 December 1868 | created Marquess of Ripon 23 June 1871 |
| Henry Bruce | 9 August 1873 | created Lord Aberdare 23 August 1873 |
| Lord Privy Seal | The Earl of Kimberley | 9 December 1868 | |
| The Viscount Halifax | 6 July 1870 |
| Secretary of State for the Home Department | Henry Bruce | 9 December 1868 | |
| Robert Lowe | 9 August 1873 |
| Under-Secretary of State for the Home Department | Edward Knatchbull-Hugessen | 10 December 1868 | |
| George Shaw-Lefevre | 11 January 1871 |
| Henry Winterbotham | 17 March 1871 |
| Secretary of State for Foreign Affairs | The Earl of Clarendon | 9 December 1868 | |
| The Earl Granville | 6 July 1870 | also Leader of the House of Lords |
| Under-Secretary of State for Foreign Affairs | Arthur Otway | 12 December 1868 | |
| Viscount Enfield | 9 January 1871 |
| Secretary of State for War | Edward Cardwell | 9 December 1868 | |
| Under-Secretary of State for War | The Lord Northbrook | 10 December 1868 | |
| The Marquess of Lansdowne | 26 April 1872 |
| Financial Secretary to the War Office | John Cranch Walker Vivian | 5 August 1870 | |
| Henry Campbell-Bannerman | 15 November 1871 |
| Surveyor-General of the Ordnance | Sir Henry Storks | 5 August 1870 | |
| Secretary of State for the Colonies | The Earl Granville | 9 December 1868 | also Leader of the House of Lords |
| The Earl of Kimberley | 6 July 1870 |
| Under-Secretary of State for the Colonies | William Monsell | 10 December 1868 | |
| Edward Knatchbull-Hugessen | 14 January 1871 |
| Secretary of State for India | The Duke of Argyll | 9 December 1868 | |
| Under-Secretary of State for India | M. E. Grant Duff | 10 December 1868 | |
| First Lord of the Admiralty | Hugh Childers | 9 December 1868 | |
| George Goschen | 24 March 1871 |
| First (later Parliamentary) Secretary to the Admiralty | William Edward Baxter | 18 December 1868 | |
| George Shaw-Lefevre | 17 March 1871 |
| Civil Lord of the Admiralty | George Trevelyan | 21 December 1868 | |
| The Earl of Camperdown | 11 July 1870 |
| Vice-President of the Committee on Education | William Edward Forster | 9 December 1868 | entered the Cabinet July 1870 |
| Chief Secretary for Ireland | Chichester Fortescue | 16 December 1868 | |
| Marquess of Hartington | 12 January 1871 |
| Lord Lieutenant of Ireland | The Earl Spencer | 18 December 1868 | |
| Chancellor of the Duchy of Lancaster | The Lord Dufferin and Clandeboye | 12 December 1868 | created Earl of Dufferin 13 November 1871 |
| Hugh Childers | 9 August 1872 | |
| John Bright | 30 September 1873 |
| President of the Poor Law Board | George Goschen | 9 December 1868 | |
| James Stansfeld | 24 March 1871 | Board abolished 14 August 1871 |
| Parliamentary Secretary to the Poor Law Board | Arthur Peel | 10 December 1868 |
| President of the Local Government Board | James Stansfeld | 19 August 1871 | |
| Parliamentary Secretary to the Local Government Board | John Tomlinson Hibbert | 19 August 1871 | |
| Postmaster-General | Marquess of Hartington | 9 December 1868 | |
| William Monsell | 14 January 1871 |
| Lyon Playfair | 18 November 1873 |
| President of the Board of Trade | John Bright | 9 December 1868 | |
| Chichester Fortescue | 14 January 1871 |
| Parliamentary Secretary to the Board of Trade | George Shaw-Lefevre | 9 December 1868 | |
| Arthur Peel | 14 January 1871 |
| Paymaster-General | The Lord Dufferin and Clandeboye | 12 December 1868 | created Earl of Dufferin 13 November 1871 |
| Hugh Childers | 9 August 1872 | |
| William Patrick Adam | 30 September 1873 |
| First Commissioner of Works | Austen Henry Layard | 9 December 1868 | |
| Acton Smee Ayrton | 26 October 1869 |
| William Patrick Adam | 11 August 1873 |
| Attorney General | Sir Robert Collier | 12 December 1868 | |
| Sir John Coleridge | 10 November 1871 |
| Sir Henry James | 20 November 1873 |
| Solicitor General | Sir John Coleridge | 12 December 1868 | |
| Sir George Jessel | 10 November 1871 |
| Sir Henry James | 26 September 1873 |
| Sir William Vernon Harcourt | 20 November 1873 |
| Judge Advocate General | Sir Colman O'Loghlen | 16 December 1868 | |
| John Robert Davison | 28 December 1870 |
| Sir Robert Phillimore | 17 May 1871 |
| Acton Smee Ayrton | 21 August 1873 |
| Lord Advocate | James Moncreiff | 10 December 1868 | |
| George Young | 14 October 1869 |
| Solicitor General for Scotland | George Young | 14 December 1868 | |
| Andrew Rutherfurd-Clark | 14 October 1869 |
| Attorney General for Ireland | Edward Sullivan | 12 December 1868 | |
| Charles Robert Barry | 26 January 1870 |
| Richard Dowse | 13 January 1872 |
| Christopher Palles | 5 November 1872 |
| Solicitor General for Ireland | Charles Robert Barry | 12 December 1868 | |
| Richard Dowse | 14 February 1870 |
| Christopher Palles | 6 February 1872 |
| Hugh Law | 18 November 1872 |
| Lord Steward of the Household | The Earl of Bessborough | 12 December 1868 | |
| Lord Chamberlain of the Household | The Viscount Sydney | 9 December 1868 | |
| Vice-Chamberlain of the Household | Viscount Castlerosse | 12 December 1868 | succeeded as 4th Earl of Kenmare 26 December 1871 |
| Lord Richard Grosvenor | 25 February 1872 | |
| Master of the Horse | The Marquess of Ailesbury | 12 December 1868 | |
| Treasurer of the Household | The Lord de Tabley | 12 December 1868 | |
| The Lord Poltimore | 1 March 1872 |
| The Lord Monson | 1 January 1874 |
| Comptroller of the Household | Lord Otho FitzGerald | 12 December 1868 | |
| Captain of the Gentlemen-at-Arms | The Lord Foley | 12 December 1868 | |
| The Marquess of Normanby | 27 December 1869 |
| The Earl Cowper | 20 April 1871 |
| The Earl of Ilchester | 1 January 1874 |
| Captain of the Yeomen of the Guard | The Duke of St Albans | 22 December 1868 | |
| Master of the Buckhounds | The Earl of Cork | 12 December 1868 | |
| Mistress of the Robes | The Duchess of Argyll | 17 December 1868 | |
| The Duchess of Sutherland | 22 January 1870 |
| Lords in Waiting | The Marquess of Normanby | 17 December 1868 – 27 December 1869 | |
| The Earl of Camperdown | 17 December 1868 – 11 July 1870 |
| The Lord Camoys | 17 December 1868 – 17 February 1874 |
| The Lord Suffield | 17 December 1868 – 25 February 1872 |
| The Lord Methuen | 17 December 1868 – 17 February 1874 |
| The Earl of Morley | 22 December 1868 – 17 February 1874 |
| The Lord Lurgan | 27 January 1869 – 17 February 1874 |
| The Lord Wrottesley | 27 December 1869 – 17 February 1874 |
| The Marquess of Huntly | 21 July 1870 – 1 March 1873 |
| The Earl of Kenmare | 25 February 1872 – 17 February 1874 |
| The Earl of Breadalbane | 1 March 1873 – 17 February 1874 |