Cytosol alanyl aminopeptidase

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Cytosol alanyl aminopeptidase (EC 3.4.11.14, arylamidase, aminopolypeptidase, thiol-activated aminopeptidase, human liver aminopeptidase, puromycin-sensitive aminopeptidase, soluble alanyl aminopeptidase, cytosol aminopeptidase III, alanine aminopeptidase) is an enzyme.^[1]^[2]^[3] This enzyme catalyses the following chemical reaction

Release of an N-terminal amino acid, preferentially alanine, from a wide range of peptides, amides and arylamides

This puromycin-sensitive enzyme is Co2+-activated zinc-sialoglycoprotein.

References

↑ Starnes, W.L. and Behal, F.J. (1974). "A human liver aminopeptidase. The amino acid and carbohydrate content, and some physical properties of a sialic acid containing glycoprotein". Biochemistry 13: 3221–3227. doi:10.1021/bi00713a004. PMID 4841062.
↑ Kao, Y.J., Starnes, W.L. and Behal, F.J. (1978). "Human kidney alanine aminopeptidase: physical and kinetic properties of a sialic acid containing glycoprotein". Biochemistry 17: 2990–2994. doi:10.1021/bi00608a008. PMID 698181.
↑ Sidorowicz, W., Hsia, W.-C., Maslej-Zownir, M. and Behal, F.J. (1980). "Multiple molecular forms of human alanine aminopeptidase: imunochemical properties". Clin. Chim. Acta 107: 245–256. doi:10.1016/0009-8981(80)90452-0. PMID 6108169.

External links

Cytosol alanyl aminopeptidase at the US National Library of Medicine Medical Subject Headings (MeSH)

Hydrolase: proteases (EC 3.4)

3.4.11-19: Exopeptidase

3.4.11	Aminopeptidase Alanine Arginyl Aspartyl Cystinyl Leucyl Glutamyl Methionyl 1 2 O

3.4.13	Dipeptidase 1 2 3

3.4.14	Dipeptidyl peptidase Cathepsin C Dipeptidyl peptidase-4 Tripeptidyl peptidase Tripeptidyl peptidase I Tripeptidyl peptidase II

3.4.15	Angiotensin-converting enzyme

3.4.16	Serine type carboxypeptidases: Cathepsin A DD-transpeptidase

3.4.17	Metalloexopeptidases Carboxypeptidase A A2 B C E Glutamate II

Other/ungrouped	Metalloexopeptidase

3.4.21-25: Endopeptidase

Other/ungrouped: Amyloid precursor protein secretase

3.4.99: Unknown

Staphylokinase

Proteins: enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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