Debrisoquine

Debrisoquine[1]
Names
IUPAC name
1,2,3,4-tetrahydroisoquinoline-2-carboximidamide
Identifiers
1131-64-2 YesY
ChEBI CHEBI:34665 YesY
ChEMBL ChEMBL169901 YesY
ChemSpider 2860 YesY
DrugBank DB04840 YesY
Jmol interactive 3D Image
KEGG C13650 YesY
MeSH Debrisoquine
PubChem 2966
UNII X31CDK040E YesY
Properties
C10H13N3
Molar mass 175.23032
Pharmacology
ATC code C02CC04
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
YesY verify (what is YesYN ?)
Infobox references

Debrisoquine is a derivative of guanidine. It is an antihypertensive drug similar to guanethidine. Debrisoquine is frequently used for phenotyping the CYP2D6 enzyme, a drug metabolizing enzyme.[2]

See also

The guanidine part of the molecule also appears in guanoxan and guanadrel.

References

  1. Debrisoquine – Compound Summary, PubChem.
  2. Fuhr, U.; Jetter, A.; Kirchheiner, J. (2007). "Appropriate Phenotyping Procedures for Drug Metabolizing Enzymes and Transporters in Humans and Their Simultaneous Use in the "Cocktail" Approach". Clinical Pharmacology & Therapeutics 81 (2): 270–283. doi:10.1038/sj.clpt.6100050.


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