Deoxyribonucleotide

A deoxyribonucleotide is the monomer, or single unit, of DNA, or deoxyribonucleic acid. Each deoxyribonucleotide comprises three parts: a nitrogenous base, a deoxyribose sugar, and one phosphate group.^[1] The nitrogenous base is always bonded to the 1' carbon of the deoxyribose, which is distinguished from ribose by the presence of a proton on the 2' carbon rather than an -OH group. The phosphate groups bind to the 5' carbon of the sugar.

When deoxyribonucleotides polymerize to form DNA, the phosphate group from one nucleotide will bond to the 3' carbon on another nucleotide, forming a phosphodiester bond via dehydration synthesis. New nucleotides are always added to the 3' carbon of the last nucleotide, so synthesis always proceeds from 5' to 3'.

References

↑ Coghill, Anne M.; Garson, Lorrin R., ed. (2006). The ACS style guide: effective communication of scientific information (3rd ed.). Washington, D.C.: American Chemical Society. p. 244. ISBN 978-0-8412-3999-9.

External links

Deoxyribonucleotides at the US National Library of Medicine Medical Subject Headings (MeSH)

Nucleic acid constituents

Nucleobase

Nucleoside

Ribonucleoside	Adenosine Guanosine 5-Methyluridine Uridine 5-Methylcytidine Cytidine Inosine Xanthosine Wybutosine

Deoxyribonucleoside	Deoxyadenosine Deoxyguanosine Thymidine Deoxyuridine Deoxycytidine Deoxyinosine Deoxyxanthosine

Nucleotide
(Nucleoside monophosphate)

Ribonucleotide	AMP GMP m⁵UMP UMP CMP IMP XMP

Deoxyribonucleotide	dAMP dGMP dTMP dUMP dCMP dIMP dXMP

Cyclic nucleotide	cAMP cGMP c-di-GMP cADPR

Nucleoside diphosphate

ADP GDP m⁵UDP UDP CDP

dADP dGDP dTDP dUDP dCDP

Nucleoside triphosphate

ATP GTP m⁵UTP UTP CTP ITP XTP

dATP dGTP dTTP dUTP dCTP dITP dXTP

This article is issued from Wikipedia - version of the Thursday, March 14, 2013. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.