Dipeptidyl-peptidase II
Dipeptidyl-peptidase II (EC 3.4.14.2, dipeptidyl aminopeptidase II, dipeptidyl arylamidase II, carboxytripeptidase, dipeptidyl peptidase II, DAP II, dipeptidyl(amino)peptidase II, dipeptidylarylamidase) is an enzyme.[1][2] This enzyme catalyses the following chemical reaction
- Release of an N-terminal dipeptide, Xaa-Yaa!, preferentially when Yaa is Ala or Pro. Substrates are oligopeptides, preferentially tripeptides
This lysosomal serine-type peptidase is maximally active at acidic pH.
References
- ↑ McDonald, J.K., Reilly, T.J., Zeitman, B.B. and Ellis, S. (1968). "Dipeptidyl arylamidase II of the pituitary. Properties of lysyl-alanyl-β-naphthylamide hydrolysis: inhibition by cations, distribution in tissues and subcellular localization". J. Biol. Chem. 243: 4143–4150. PMID 4969969.
- ↑ McDonald, J.K. and Schwabe, C. (1977). "Intracellular exopeptidases". In Barrett, A.J. Proteinases in Mammalian Cells and Tissues. Amsterdam: North-Holland Publishing Co. pp. 311–391.
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