HuD (protein)

ELAV like neuron-specific RNA binding protein 4
PDB rendering based on 1fxl.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1FXL​, 1G2E​
Identifiers
Symbols	ELAVL4 ; HUD; PNEM
External IDs	OMIM: 168360 MGI: 107427 HomoloGene: 40729 GeneCards: ELAVL4 Gene
Gene ontology Molecular function • nucleotide binding • RNA binding • mRNA 3'-UTR binding • AU-rich element binding Biological process • RNA processing • mRNA processing Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1996	15572
Ensembl	ENSG00000162374	ENSMUSG00000028546
UniProt	P26378	Q61701
RefSeq (mRNA)	NM_001144774	NM_001038698
RefSeq (protein)	NP_001138246	NP_001033787
Location (UCSC)	Chr 1: 50.05 – 50.2 Mb	Chr 4: 110.2 – 110.35 Mb
PubMed search

HuD otherwise known as ELAV-like protein 4 is a protein that in humans is encoded by the ELAVL4 gene.^[1][2]

The HuD/ELAVL4 protein is an RNA-binding protein.^[3]

HuD is expressed only in neurons and it binds to AU-rich element-containing mRNAs. As a result of this interaction the half-life of the transcript is increased. HuD is important in neurons during brain development and plasticity.^[4][5]

Interactions

HuD (protein) has been shown to interact with NXF1.^[6]

References

1. Muresu R, Baldini A, Gress T, Posner JB, Furneaux HM, Siniscalco M (Dec 1993). "Mapping of the gene coding for a paraneoplastic encephalomyelitis antigen (HuD) to human chromosome site 1p34". Cytogenet Cell Genet 65 (3): 177–8. doi:10.1159/000133626. PMID 8222755.
2. "Entrez Gene: ELAVL4 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)".
3. Szabo A, Dalmau J, Manley G, et al. (1991). "HuD, a paraneoplastic encephalomyelitis antigen, contains RNA-binding domains and is homologous to Elav and Sex-lethal.". Cell 67 (2): 325–33. doi:10.1016/0092-8674(91)90184-Z. PMID 1655278.
4. Nora Perrone-Bizzozero and Federico Bolognani (2002). "Role of HuD and other RNA-binding proteins in neural development and plasticity". J Neurosci Res 68 (2): 121–126. doi:10.1002/jnr.10175. PMID 11948657.
5. Federico Bolognani and Nora Perrone-Bizzozero (2008). "RNA-protein interactions and control of mRNA stability in neurons". J Neurosci Res 86 (3): 481–489. doi:10.1002/jnr.21473. PMID 17853436.
6. Saito, Kuniaki; Fujiwara Toshinobu; Katahira Jun; Inoue Kunio; Sakamoto Hiroshi (Aug 2004). "TAP/NXF1, the primary mRNA export receptor, specifically interacts with a neuronal RNA-binding protein HuD". Biochem. Biophys. Res. Commun. (United States) 321 (2): 291–7. doi:10.1016/j.bbrc.2004.06.140. ISSN 0006-291X. PMID 15358174.

Further reading

• Dalmau J, Furneaux HM, Cordon-Cardo C, Posner JB (1992). "The expression of the Hu (paraneoplastic encephalomyelitis/sensory neuronopathy) antigen in human normal and tumor tissues.". Am. J. Pathol. 141 (4): 881–6. PMC 1886624. PMID 1415481.
• Szabo A, Dalmau J, Manley G, et al. (1991). "HuD, a paraneoplastic encephalomyelitis antigen, contains RNA-binding domains and is homologous to Elav and Sex-lethal.". Cell 67 (2): 325–33. doi:10.1016/0092-8674(91)90184-Z. PMID 1655278.
• Graus F, Ferrer I (1990). "Analysis of a neuronal antigen (Hu) expression in the developing rat brain detected by autoantibodies from patients with paraneoplastic encephalomyelitis.". Neurosci. Lett. 112 (1): 14–8. doi:10.1016/0304-3940(90)90314-Y. PMID 2166930.
• Sekido Y, Bader SA, Carbone DP, et al. (1994). "Molecular analysis of the HuD gene encoding a paraneoplastic encephalomyelitis antigen in human lung cancer cell lines.". Cancer Res. 54 (18): 4988–92. PMID 8069866.
• Torà M, Graus F, de Bolòs C, Real FX (1997). "Cell surface expression of paraneoplastic encephalomyelitis/sensory neuronopathy-associated Hu antigens in small-cell lung cancers and neuroblastomas.". Neurology 48 (3): 735–41. doi:10.1212/wnl.48.3.735. PMID 9065557.
• Lazarova DL, Spengler BA, Biedler JL, Ross RA (1999). "HuD, a neuronal-specific RNA-binding protein, is a putative regulator of N-myc pre-mRNA processing/stability in malignant human neuroblasts.". Oncogene 18 (17): 2703–10. doi:10.1038/sj.onc.1202621. PMID 10348344.
• Park S, Myszka DG, Yu M, et al. (2000). "HuD RNA recognition motifs play distinct roles in the formation of a stable complex with AU-rich RNA.". Mol. Cell. Biol. 20 (13): 4765–72. doi:10.1128/MCB.20.13.4765-4772.2000. PMC 85909. PMID 10848602.
• Wang X, Tanaka Hall TM (2001). "Structural basis for recognition of AU-rich element RNA by the HuD protein.". Nat. Struct. Biol. 8 (2): 141–5. doi:10.1038/84131. PMID 11175903.
• Beckel-Mitchener AC, Miera A, Keller R, Perrone-Bizzozero NI (2002). "Poly(A) tail length-dependent stabilization of GAP-43 mRNA by the RNA-binding protein HuD.". J. Biol. Chem. 277 (31): 27996–8002. doi:10.1074/jbc.M201982200. PMID 12034726.
• Behrends U, Jandl T, Golbeck A, et al. (2002). "Novel products of the HUD, HUC, NNP-1 and alpha-internexin genes identified by autologous antibody screening of a pediatric neuroblastoma library.". Int. J. Cancer 100 (6): 669–77. doi:10.1002/ijc.10550. PMID 12209604.
• Aronov S, Aranda G, Behar L, Ginzburg I (2003). "Visualization of translated tau protein in the axons of neuronal P19 cells and characterization of tau RNP granules.". J. Cell. Sci. 115 (Pt 19): 3817–27. doi:10.1242/jcs.00058. PMID 12235292.
• Angenstein F, Evans AM, Settlage RE, et al. (2002). "A receptor for activated C kinase is part of messenger ribonucleoprotein complexes associated with polyA-mRNAs in neurons.". J. Neurosci. 22 (20): 8827–37. PMID 12388589.
• Deschenes-Furry J, Belanger G, Perrone-Bizzozero N, Jasmin BJ (2003). "Post-transcriptional regulation of acetylcholinesterase mRNAs in nerve growth factor-treated PC12 cells by the RNA-binding protein HuD.". J. Biol. Chem. 278 (8): 5710–7. doi:10.1074/jbc.M209383200. PMID 12468554.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Plonquet A, Garcia-Pons F, Fernandez E, et al. (2004). "Peptides derived from the onconeural HuD protein can elicit cytotoxic responses in HHD mouse and human.". J. Neuroimmunol. 142 (1-2): 93–100. doi:10.1016/S0165-5728(03)00269-8. PMID 14512168.
• Saito K, Fujiwara T, Katahira J, et al. (2004). "TAP/NXF1, the primary mRNA export receptor, specifically interacts with a neuronal RNA-binding protein HuD.". Biochem. Biophys. Res. Commun. 321 (2): 291–7. doi:10.1016/j.bbrc.2004.06.140. PMID 15358174.
• Rousseau A, Benyahia B, Dalmau J, et al. (2005). "T cell response to Hu-D peptides in patients with anti-Hu syndrome.". J. Neurooncol. 71 (3): 231–6. doi:10.1007/s11060-004-1723-1. PMC 2586925. PMID 15735910.
• Noureddine MA, Qin XJ, Oliveira SA, et al. (2005). "Association between the neuron-specific RNA-binding protein ELAVL4 and Parkinson disease.". Hum. Genet. 117 (1): 27–33. doi:10.1007/s00439-005-1259-2. PMID 15827745.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.