Pseudomonas exotoxin

The Pseudomonas exotoxin (or exotoxin A) is an exotoxin produced by Pseudomonas aeruginosa.^[1]

It inhibits elongation factor-2.^[2] It does so by ADP-ribosylation of EF2. This then causes the elongation of polypeptides to cease.(The mechanism of the toxin is similar to that of Diphtheria toxin.)

It has been investigated as a treatment for hepatitis B^[3] and cancer.^[4]

References

↑ Yates SP, Taylor PL, Jørgensen R, et al. (February 2005). "Structure-function analysis of water-soluble inhibitors of the catalytic domain of exotoxin A from Pseudomonas aeruginosa". Biochem. J. 385 (Pt 3): 667–75. doi:10.1042/BJ20041480. PMC 1134741. PMID 15458385.
↑ Yates SP, Merrill AR (May 2004). "Elucidation of eukaryotic elongation factor-2 contact sites within the catalytic domain of Pseudomonas aeruginosa exotoxin A". Biochem. J. 379 (Pt 3): 563–72. doi:10.1042/BJ20031731. PMC 1224111. PMID 14733615.
↑ Hafkemeyer P, Brinkmann U, Brinkmann E, Pastan I, Blum HE, Baumert TF (May 2008). "Pseudomonas exotoxin antisense RNA selectively kills hepatitis B virus infected cells". World J. Gastroenterol. 14 (18): 2810–7. doi:10.3748/wjg.14.2810. PMC 2710720. PMID 18473403.
↑ Stuckey, Daniel; Hingtgen, Shawn; Karaka, Nihal; Rich, Benjamin; Shah, Khalid (2014). "Engineering toxin-resistant therapeutic stem cells to treat brain tumors". Stem Cells (AlphaMed Express) 33: 589–600. doi:10.1002/stem.1874. PMID 25346520.

Toxins

Clostridium:	tetani Tetanospasmin Tetanolysin perfringens Alpha toxin Enterotoxin difficile A B botulinum Botox

other:	Anthrax toxin Listeriolysin O

Cocci

Streptolysin Leukocidin Panton-Valentine leukocidin

Staphylococcus	Staphylococcus aureus alpha/beta/delta Exfoliatin Toxic shock syndrome toxin Staphylococcal Enterotoxin B (SEB)

Plant toxins

Invertebrate toxins

scorpion:	Androctonus australis hector insect toxin Charybdotoxin Maurotoxin Agitoxin Margatoxin Slotoxin Scyllatoxin Hefutoxin Lq2 Birtoxin Bestoxin BmKAEP Phaiodotoxin Imperatoxin Pi3

spider:	Latrotoxin Alpha-latrotoxin CSTX Cupiennins PhTx3 Stromatoxin Vanillotoxin Huwentoxin

mollusca:	Conotoxin Eledoisin Onchidal Saxitoxin Tetrodotoxin

Vertebrate toxins

fish:	Ciguatera Tetrodotoxin

amphibian:	(+)-Allopumiliotoxin 267A Batrachotoxin Bufotoxins Arenobufagin Bufotalin Bufotenin Cinobufagin Marinobufagin Epibatidine Histrionicotoxin Pumiliotoxin 251D Samandarin Samandaridine Tarichatoxin

reptile/snake venom:	Bungarotoxin Alpha-Bungarotoxin Beta-Bungarotoxin Calciseptine Taicatoxin Calcicludine Cardiotoxin III

note: some toxins are produced by lower species and pass through intermediate species

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Commons
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