Dimethylallyltranstransferase

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PubMed	articles
NCBI	proteins

farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase)
Identifiers
Symbol	FDPS
Entrez	2224
HUGO	3631
OMIM	134629
RefSeq	NM_002004
UniProt	P14324
Other data
EC number	2.5.1.1
Locus	Chr. 1 q22

Dimethylallyltranstransferase is an enzyme that converts dimethylallylpyrophosphate and isopentenyl pyrophosphate into farnesylpyrophosphate.^[1]^[2] It is also referred to as farnesylpyrophosphate synthase or farnesyldiphosphate synthase.

Pyrophosphate is also involved, as both a reactant and a product. Geranylpyrophosphate is created in an intermediate step.

References

↑ Banthorpe, D.V., Bucknall, G.A., Doonan, H.J., Doonan, S. and Rowan, M.G. (1976). "Biosynthesis of geraniol and nerol in cell-free extracts of Tanacetum vulgare". Phytochemistry 15: 91–100.
↑ Sagami, H., Ogura, K., Seto, S. and Kurokawa, T. (1978). "A new prenyltransferase from Micrococcus lysodeikticus". Biochem. Biophys. Res. Commun. 85: 572–578. PMID 736921.

External links

Dimethylallyltranstransferase at the US National Library of Medicine Medical Subject Headings (MeSH)

Metabolism: lipid metabolism – ketones/cholesterol synthesis enzymes/steroid metabolism

Mevalonate pathway

To HMG-CoA	Acetyl-Coenzyme A acetyltransferase HMG-CoA synthase (regulated step)

Ketogenesis	HMG-CoA lyase 3-hydroxybutyrate dehydrogenase Thiophorase

To Mevalonic acid	HMG-CoA reductase

To DMAPP	Mevalonate kinase Phosphomevalonate kinase Pyrophosphomevalonate decarboxylase Isopentenyl-diphosphate delta isomerase

Geranyl-	Dimethylallyltranstransferase Geranyl pyrophosphate

To cholesterol

To lanosterol	Farnesyl-diphosphate farnesyltransferase Squalene monooxygenase Lanosterol synthase

7-Dehydrocholesterol path	Lanosterol 14α-demethylase Sterol-C5-desaturase-like 7-Dehydrocholesterol reductase

Desmosterol path	24-dehydrocholesterol reductase

To Bile acids

Steroidogenesis

To pregnenolone

Side-chain cleavage

To corticosteroids

aldosterone: 18-hydroxylase

To sex hormones

To androgens	17α-hydroxylase/17,20 lyase 3β dehydrogenase 17β dehydrogenase 5α reductase 1 2

To estrogens	Aromatase

Other/ungrouped

Transferases: alkyl and aryl (EC 2.5)

2.5.1	Dimethylallyltranstransferase Thiaminase I Methionine adenosyltransferase Riboflavin synthase Dihydropteroate synthase Spermidine synthase Glutathione S-transferase Farnesyl-diphosphate farnesyltransferase Spermine synthase Alkylglycerone phosphate synthase Farnesyltransferase Geranylgeranyltransferase type 1 Porphobilinogen deaminase

Proteins: enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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Dimethylallyltranstransferase

References

See also

External links