X-Pro dipeptidase

Xaa-Pro dipeptidase (EC 3.4.13.9, prolidase, imidodipeptidase, proline dipeptidase, peptidase D, gamma-peptidase) is an enzyme.^[1]^[2]^[3]^[4] This enzyme catalyses the following chemical reaction

Hydrolysis of Xaa!Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs

This enzyme is Mn²⁺-activated.

References

↑ Davis, N.C. and Smith, E.L. (1957). "Purification and some properties of prolidase of swine kidney". J. Biol. Chem. 224: 261–275. PMID 13398404.
↑ Sjöström, H., Norén, O. and Josefsson, L. (1973). "Purification and specificity of pig intestinal prolidase". Biochim. Biophys. Acta 327: 457–470. doi:10.1016/0005-2744(73)90429-4. PMID 4778946.
↑ Baksi, K. and Radhakrishnan, A.N. (1974). "Purification and properties of prolidase (imidodipeptidase) from monkey small intestine". Indian J. Biochem. Biophys. 11: 7–11. PMID 4435812.
↑ Browne, P. and O'Cuinn, G. (1983). "The purification and characterization of a proline dipeptidase from guinea pig brain". J. Biol. Chem. 258: 6147–6154. PMID 6853481.

External links

Xaa-Pro dipeptidase at the US National Library of Medicine Medical Subject Headings (MeSH)

Hydrolase: proteases (EC 3.4)

3.4.11-19: Exopeptidase

3.4.11	Aminopeptidase Alanine Arginyl Aspartyl Cystinyl Leucyl Glutamyl Methionyl 1 2 O

3.4.13	Dipeptidase 1 2 3

3.4.14	Dipeptidyl peptidase Cathepsin C Dipeptidyl peptidase-4 Tripeptidyl peptidase Tripeptidyl peptidase I Tripeptidyl peptidase II

3.4.15	Angiotensin-converting enzyme

3.4.16	Serine type carboxypeptidases: Cathepsin A DD-transpeptidase

3.4.17	Metalloexopeptidases Carboxypeptidase A A2 B C E Glutamate II

Other/ungrouped	Metalloexopeptidase

3.4.21-25: Endopeptidase

Other/ungrouped: Amyloid precursor protein secretase

3.4.99: Unknown

Staphylokinase

Proteins: enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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