Intermediate cleaving peptidase 55
Intermediate cleaving peptidase 55 (EC 3.4.11.26, Icp55, mitochondrial intermediate cleaving peptidase 55 kDa) is an enzyme.[1][2] This enzyme catalyses the following chemical reaction
- The enzyme cleaves the Pro36-Pro37 bond of cysteine desulfurase (EC 2.8.1.7) removing three amino acid residues (Tyr-Ser-Pro) from the N-terminus after cleavage by mitochondrial processing peptidase.
Icp55 removes the destabilizing N-terminal amino acid residues.
References
- ↑ Naamati, A., Regev-Rudzki, N., Galperin, S., Lill, R. and Pines, O. (2009). "Dual targeting of Nfs1 and discovery of its novel processing enzyme, Icp55". J. Biol. Chem. 284: 30200–30208. doi:10.1074/jbc.M109.034694. PMID 19720832.
- ↑ Vogtle, F.N., Wortelkamp, S., Zahedi, R.P., Becker, D., Leidhold, C., Gevaert, K., Kellermann, J., Voos, W., Sickmann, A., Pfanner, N. and Meisinger, C. (2009). "Global analysis of the mitochondrial N-proteome identifies a processing peptidase critical for protein stability". Cell 139: 428–439. doi:10.1016/j.cell.2009.07.045. PMID 19837041.
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