J. B. S. Haldane

J. B. S. Haldane

Haldane in 1914
Born (1892-11-05)5 November 1892
Oxford, England
Died 1 December 1964(1964-12-01) (aged 72)
Bhubaneswar, India
Residence

United Kingdom

  • United States
  • India
Nationality British (until 1961)
Indian
Fields
Institutions

University of Cambridge

University College London

Education Eton College
Alma mater New College, Oxford
Academic advisors Frederick Gowland Hopkins
Doctoral students Helen Spurway
Krishna Dronamraju
John Maynard Smith
Known for Oparin-Haldane hypothesis
Malaria theory
Population genetics
Enzymology
Neo-Darwinism
Notable awards 1958  Darwin–Wallace Medal
1952  Darwin Medal
Spouse

1926–45  Charlotte Haldane

1945–64 Helen Spurway

Military career

Allegiance  United Kingdom
Service/branch  British Army
Years of service 1914-1920
Rank Captain
Battles/wars First World War

John Burdon Sanderson Haldane, FRS (/ˈhɔːldeɪn/; 5 November 1892 – 1 December 1964)[1] was a British-born Indian scientist known for his work in the study of physiology, genetics, evolutionary biology, and in mathematics, where he made innovative contributions to the fields of statistics and biostatistics. He was the son of the equally famous John Scott Haldane and a professed socialist, Marxist, atheist, and humanist whose political dissent led him to leave England in 1956 and live in India, becoming a naturalised Indian citizen in 1961.

His first paper in 1915 demonstrated genetic linkage in mammals while subsequent works helped to create population genetics, thus establishing a unification of Mendelian genetics and Darwinian evolution by natural selection whilst laying the groundwork for modern evolutionary synthesis. His article on abiogenesis in 1929 introduced the "Primordial Soup Theory", and it became the foundation to build physical models for the chemical origin of life. Haldane established human gene maps for haemophilia and colour blindness on the X chromosome, and codified Haldane's rule on sterility in the heterogametic sex of hybrids in species.[2][3] He correctly proposed that sickle-cell disease confers some immunity to malaria. He was the first to suggest the central idea of in vitro fertilisation, as well as concepts such as the: hydrogen economy, cis and trans-acting regulation, coupling reaction, molecular repulsion, darwin (as a unit of evolution) and organismal cloning. In 1957 he articulated Haldane's dilemma, a limit on the speed of beneficial evolution which subsequently proved incorrect. He willed his body for medical studies, as he wanted to remain useful even in death.[4]

Arthur C. Clarke credited him as "perhaps the most brilliant science populariser of his generation".[5][6] Nobel laureate Peter Medawar called Haldane "the cleverest man I ever knew".[7]

Biography

His father John Scott Haldane c. 1910

Early life and education

Haldane was born in Oxford to John Scott Haldane, a physiologist, scientist, a philosopher and a Liberal, and Louisa Kathleen Trotter, a Conservative. His younger sister, Naomi Mitchison, became a writer, while his uncle was Viscount Haldane and his aunt the author Elizabeth Haldane. Descended from an aristocratic and secular family[8] of the Clan Haldane, he would later claim that his Y chromosome could be traced back to Robert the Bruce.[9]

He grew up at 11 Crick Road, North Oxford.[10] He learnt to read age three and age four, after he injured himself on the forehead he asked the doctor, "Is this oxyhemoglobin or carboxyhemoglobin?". From age eight he worked with his father in their home laboratory where he experienced his first self-experimentation, the method he would later be famous for. He and his father became their own "human guinea pigs", such as in their investigation on the effects of poison gases. In 1899 his family moved to "Cherwell", a late Victorian house at the outskirts of Oxford having its private laboratory.

His formal education began in 1897 at Oxford Preparatory School (now Dragon School), where he gained a First Scholarship in 1904 to Eton. In 1905 he joined Eton, where he experienced severe abuse from senior students for allegedly being arrogant. The indifference of authority left him with a lasting hatred for the English education system. However, the ordeal did not stop him from becoming Captain of the school. He studied mathematics and classics at New College at the University of Oxford and obtained first-class honours in mathematical moderations in 1912 and a first-class honours in 1914. With his father he published his first scientific paper, age 20. He became engrossed in genetics and presented a paper on gene linkage in vertebrates in the summer of 1912. His first technical paper, a 30-page long article on haemoglobin function, was published, as a co-author alongside his father.[11]

Career

His education was interrupted by the First World War during which he fought in the British Army, being commissioned a temporary second lieutenant in the 3rd Battalion of the Black Watch (Royal Highland Regiment) on 15 August 1914.[12] He was promoted to temporary lieutenant on 18 February 1915 and to temporary captain on 18 October.[13][14] He served in France and Iraq, where he was wounded. He relinquished his commission on 1 April 1920, retaining his rank of captain.[15] For his ferocity and aggressiveness in battles, his commander called him the "bravest and dirtiest officer in my Army."[16]

Between 1919 and 1922 he was a Fellow of New College, Oxford,[17] where he researched physiology and genetics. He then moved to the Cambridge University, where he accepted a readership in Biochemistry at Trinity College in the University of Cambridge and taught until 1932.[8] From 1927 until 1937 he was also Head of Genetical Research at the John Innes Horticultural Institution.[18] During his nine years at Cambridge, Haldane worked on enzymes and genetics, particularly the mathematical side of genetics.[8] He was the Fullerian Professor of Physiology at the Royal Institution from 1930 to 1932 and in 1933 he became full Professor of Genetics at University College London, where he spent most of his academic career.[19] Four years later he became the first Weldon Professor of Biometry at University College London.[8]

In 1924, Haldane met Charlotte Franken. So that they could marry, Charlotte divorced her husband, Jack Burghes, causing some controversy. Haldane was almost dismissed from Cambridge for the way he handled his meeting with her, which led to the divorce. They married in 1926. Following their separation in 1942, the Haldanes divorced in 1945. He later married Helen Spurway.

Haldane, inspired by his father, would expose himself to danger to obtain data. To test the effects of acidification of the blood he drank dilute hydrochloric acid, enclosed himself in an airtight room containing 7% carbon dioxide, and found that it 'gives one a rather violent headache'. One experiment to study elevated levels of oxygen saturation triggered a fit which resulted in him suffering crushed vertebrae.[20] In his decompression chamber experiments, he and his volunteers suffered perforated eardrums. But, as Haldane stated in What is Life, "the drum generally heals up; and if a hole remains in it, although one is somewhat deaf, one can blow tobacco smoke out of the ear in question, which is a social accomplishment."[21]

India

Marcello Siniscalco (standing) and J.B.S. Haldane in Andhra Pradesh, India, 1964
J.B.S. Haldane Avenue in Kolkata, the busy connecting road from Eastern Metropolitan Bypass to Park Circus area on which the Science City is located, is named after him
Lantana camara
Vanellus malabaricus

In 1956, Haldane left University College London, and joined the Indian Statistical Institute (ISI) in Kolkata, India,[22] where he headed the biometry unit. Officially he stated that he left the UK because of the Suez Crisis, writing: "Finally, I am going to India because I consider that recent acts of the British Government have been violations of international law." He believed that the warm climate would do him good, and that India shared his socialist dreams.[23] The university had sacked his wife Helen for excessive drinking and refusing to pay a fine, triggering Haldane's resignation. He declared he would no longer wear socks, "Sixty years in socks is enough."[24] and always dressed in Indian attire.[6]

He was keenly interested in inexpensive research. He wrote to Julian Huxley about his observations on Vanellus malabaricus, the yellow-wattled Lapwing. He advocated the use of Vigna sinensis (cowpea) as a model for studying plant genetics. He took an interest in the pollination of Lantana camara. He lamented that Indian universities forced those who took up biology to drop mathematics.[25] Haldane took an interest in the study of floral symmetry. In January 1961 he befriended Gary Botting, 1960 U.S. Science Fair winner in zoology (who had first visited the Haldanes along with Susan Brown, 1960 U.S. National Science Fair winner in botany), inviting him to share the results of his experiments hybridising Antheraea silk moths. J.B.S., his wife Helen Spurway, and Krishna Dronamraju were present at the Oberoi Grand Hotel in Kolkata when Brown reminded the Haldanes that she and Botting had a previously scheduled event that would prevent them from accepting an invitation to a banquet proposed by J.B.S. and Helen in their honour and had regretfully declined the honor. After the two students had left the hotel, Haldane went on his much-publicized hunger strike to protest what he regarded as a “U.S. insult."[26][27] When the director of the ISI, P. C. Mahalanobis, confronted Haldane about both the hunger strike and the unbudgeted banquet; Haldane resigned from his post, in February 1961, and moved to a newly established biometry unit in Odisha.[23]

Haldane became an Indian citizen.[22] He was also interested in Hinduism and became a vegetarian.[23] In 1961, Haldane described India as "the closest approximation to the Free World." Jerzy Neyman objected that "India has its fair share of scoundrels and a tremendous amount of poor unthinking and disgustingly subservient individuals who are not attractive."[22] Haldane retorted:

“ Perhaps one is freer to be a scoundrel in India than elsewhere. So one was in the U.S.A in the days of people like Jay Gould, when (in my opinion) there was more internal freedom in the U.S.A than there is today. The "disgusting subservience" of the others has its limits. The people of Calcutta riot, upset trams, and refuse to obey police regulations, in a manner which would have delighted Jefferson. I don't think their activities are very efficient, but that is not the question at issue. ”

When on 25 June 1962 he was described in print as a "Citizen of the World" by Groff Conklin, Haldane's response was as follows:[22]

“ No doubt I am in some sense a citizen of the world. But I believe with Thomas Jefferson that one of the chief duties of a citizen is to be a nuisance to the government of his state. As there is no world state, I cannot do this. On the other hand, I can be, and am, a nuisance to the government of India, which has the merit of permitting a good deal of criticism, though it reacts to it rather slowly. I also happen to be proud of being a citizen of India, which is a lot more diverse than Europe, let alone the U.S.A, the U.S.S.R or China, and thus a better model for a possible world organisation. It may of course break up, but it is a wonderful experiment. So, I want to be labeled as a citizen of India. ”

Death

Shortly before his death from cancer, Haldane wrote a comic poem while in the hospital, mocking his own incurable disease. It was read by his friends, who appreciated the consistent irreverence with which Haldane had lived his life. The poem first appeared in print in the 21 February 1964 issue of the New Statesman, and runs:[28][29]

"Cancer’s a Funny Thing:
I wish I had the voice of Homer
To sing of rectal carcinoma,
This kills a lot more chaps, in fact,
Than were bumped off when Troy was sacked..."

The poem ends:

"... I know that cancer often kills,
But so do cars and sleeping pills;
And it can hurt one till one sweats,
So can bad teeth and unpaid debts.
A spot of laughter, I am sure,
Often accelerates one’s cure;
So let us patients do our bit
To help the surgeons make us fit."

Haldane died on 1 December 1964. He willed that his body be used for study at the Rangaraya Medical College, Kakinada.[30]

“ My body has been used for both purposes during my lifetime and after my death, whether I continue to exist or not, I shall have no further use for it, and desire that it shall be used by others. Its refrigeration, if this is possible, should be a first charge on my estate.[31] ”

Academic achievements

With his sister Naomi Mitchison he started investigating Mendelian genetics in 1908, used guinea pigs and mice, publishing Reduplication in mice in 1915[32] the first demonstration of genetic linkage in mammals,[33] (As the paper was written during Haldane's service in the First World War, James F. Crow called it "the most important science article ever written in a front-line trench.[34]) He demonstrated the same phenomenon in chickens in 1921.[35]

Following his father's footsteps, Haldane's first publication was on the mechanism of gaseous exchange by haemoglobin.[11] and subsequently worked on the chemical properties of blood as a pH buffer.[36][37] He investigated several aspects of kidney functions and mechanism of excretion.[38][39]

In 1925, with G. E. Briggs, Haldane derived a new interpretation of the enzyme kinetics law described by Victor Henri in 1903, different from the 1913 Michaelis–Menten equation. Leonor Michaelis and Maud Menten assumed that enzyme (catalyst) and substrate (reactant) are in fast equilibrium with their complex, which then dissociates to yield product and free enzyme. The Briggs–Haldane equation was of the same algebraic form; but their derivation is based on the quasi-steady state approximation, which is the concentration of intermediate complex (or complexes) does not change. As a result, the microscopic meaning of the "Michaelis Constant" (Km) is different. Although commonly referring to it as Michaelis–Menten kinetics, most of the current models typically use the Briggs–Haldane derivation.[40][41]

He was one of the three major figures to develop the mathematical theory of population genetics, along with Ronald Fisher and Sewall Wright. Thusly he played an important role in the modern evolutionary synthesis, which is popularly called "neo-Darwinism", as in Richard Dawkins' 1976 work titled The Selfish Gene. He re-established natural selection as the premier mechanism of evolution by explaining it in terms of the mathematical consequences of Mendelian inheritance.[42][43] He wrote a series of ten papers called A Mathematical Theory of Natural and Artificial Selection, on the numerical formalism underpinning natural selection. It showed that gene frequencies have direction and rates of change; and he pioneered the interaction of natural selection with mutation and animal migration. Haldane's book, The Causes of Evolution (1932), summarised these results, especially in its extensive appendix.

His contributions to statistical human genetics included: the first methods using maximum likelihood for the estimation of human linkage maps; pioneering methods for estimating human mutation rates; the first estimates of mutation rate in humans, at 2 × 10−5 mutations per gene per generation for the X-linked haemophilia gene; and the first notion that there is a "cost of natural selection".[44] At the John Innes Horticultural Institution, he developed the complicated linkage theory for polyploids;[18] and extended the idea of gene/enzyme relationships with the biochemical and genetic study of plant pigments. In his essay On Being the Right Size he outlines Haldane's principle, which states that the size very often defines what bodily equipment an animal must have: "Insects, being so small, do not have oxygen-carrying bloodstreams. What little oxygen their cells require can be absorbed by simple diffusion of air through their bodies. But being larger means an animal must have complicated oxygen pumping and distributing systems to reach all the cells." The conceptual metaphor to animal allometry has been of use in energy economics and secession ideas.[45][46]

Haldane introduced the modern concept of abiogenesis in an eight-page article titled The origin of life in the Rationalist Annual in 1929,[47] describing the primitive ocean as a "vast chemical laboratory" containing a mixture of inorganic compounds – like a "hot dilute soup" in which organic compounds could have formed. Under the solar energy the anoxic atmosphere containing carbon dioxide, ammonia and water vapour gave rise to a variety of organic compounds, "living or half-living things". The first molecules reacted with one another to produce more complex compounds, and ultimately the cellular components. At some point a kind of "oily film" was produced that enclosed self-replicating nucleic acids, thereby becoming the first cell. J.D. Bernal named the hypothesis biopoiesis or biopoesis, the process of living matter spontaneously evolving from self-replicating but lifeless molecules. Haldane further hypothesised that viruses were the intermediate entities between the prebiotic soup and the first cells. He asserted that prebiotic life would have been "in the virus stage for many millions of years before a suitable assemblage of elementary units was brought together in the first cell."[47] The idea was generally dismissed as "wild speculation".[48] In 1924 Alexander Oparin had suggested similar idea in Russian, and in 1936 he introduced it to the English-speaking people. The experimental basis of the theory began in 1953 with the classic Miller–Urey experiment. Since then, the primordial soup theory became a dominant theory in the chemistry of life, and often is attributed as the Oparin-Haldane hypothesis.[49][50][51]

He proposed in 1949 that genetic disorders in humans living in malaria-endemic regions provide a phenotype with immunity to blood-borne haemophiles. He noted that mutations expressed in red blood cells, such as sickle-cell anemia and various thalassemias, were prevalent only in tropical regions where malaria has been endemic and were favourable traits for natural selection that protected individuals from receiving malarial infection.[52] This concept of resistance to malaria was eventually confirmed by A.C. Allison in 1954.[53][54]

Political views

A Low cartoon featuring Haldane – "Prophesies for 1949"
Lysenko speaking at the Kremlin in 1935. Behind him are (left to right) Stanislav Kosior, Anastas Mikoyan, Andrei Andreev and Joseph Stalin.
Nikolai Vavilov

Haldane became a socialist during the First World War; supported the Second Spanish Republic during the Spanish Civil War; and then became an open supporter of the Communist Party in 1937; being a pragmatic and dialectical materialist Marxist, writing many articles for the Daily Worker. In On Being the Right Size, he wrote: "while nationalization of certain industries is an obvious possibility in the largest of states, I find it no easier to picture a completely socialized British Empire or United States than an elephant turning somersaults or a hippopotamus jumping a hedge."

In 1938, he proclaimed enthusiastically that "I think that Marxism is true." He joined the Communist Party of Great Britain in 1942. The first edition of his children's book My Friend Mr. Leakey contained an avowal of his party membership which was removed from later editions. He was pressed to speak out about the rise of Lysenkoism and the persecution of geneticists in the Soviet Union as anti-Darwinist and the denouncement of genetics as incompatible with dialectical materialism. He shifted the focus to the United Kingdom and a criticism of the dependence of scientific research on financial patronage. In 1941 he wrote about the Soviet trial of his friend and fellow geneticist Nikolai Vavilov:

“ The controversy among Soviet geneticists has been largely one between the academic scientist, represented by Vavilov and interested primarily in the collection of facts, and the man who wants results, represented by Lysenko. It has been conducted not with venom, but in a friendly spirit. Lysenko said (in the October discussions of 1939): 'The important thing is not to dispute; let us work in a friendly manner on a plan elaborated scientifically. Let us take up definite problems, receive assignments from the People's Commissariat of Agriculture of the USSR and fulfil them scientifically. Soviet genetics, as a whole, is a successful attempt at synthesis of these two contrasted points of view.' ”

By the end of the Second World War Haldane had become an explicit critic of the regime. He left the party in 1950, shortly after considering standing for Parliament as a Communist Party candidate. He continued to admire Joseph Stalin, describing him in 1962 as "a very great man who did a very good job".[16]

Author and visionary

Haldane was parodied as "the biologist too absorbed in his experiments to notice his friends bedding his wife" by his friend Aldous Huxley in the novel Antic Hay (1923). His essay Daedalus; or, Science and the Future (1924), about ectogenesis and in vitro fertilisation was an influence on Huxley's Brave New World (1932). Haldane's work was also admired by Gerald Heard.[55] Various essays on science were collected and published in a volume titled Possible Worlds in 1927. His book, A.R.P. (Air Raid Precautions) (1938) combined his physiological research into the effects of stress upon the human body with his experience of air raids during the Spanish Civil War to provide a scientific explanation of the air raids that Britain was to endure during the Second World War.

Along with Olaf Stapledon, Charles Kay Ogden, I. A. Richards, and H. G. Wells, Haldane was accused by C. S. Lewis of scientism. Haldane criticised the Ransom Trilogy and Lewis for the "complete mischaracterisation of science, and his disparagement of the human race".[56] He wrote a book for children titled My Friend Mr Leakey (1937), containing the stories "A Meal With a Magician", "A Day in the Life of a Magician", "Mr Leakey's Party", "Rats", "The Snake with the Golden Teeth", and "My Magic Collar Stud"; later editions featured illustrations by Quentin Blake. Haldane edited Gary Botting's manuscript on the genetics of giant silk moths with margin notes.

In 1923, in a talk given in Cambridge titled "Science and the Future", Haldane, foreseeing the exhaustion of coal for power generation in Britain, proposed a network of hydrogen-generating windmills. This is the first proposal of the hydrogen-based renewable energy economy.[57][58][59]

In his An Autobiography in Brief, written shortly before his death in India, Haldane named four close associates as those showing promise to become illustrious scientists: T. A. Davis, K. R. Dronamraju, S. D. Jayakar and S. K. Roy.[60]

Haldane was the first to have thought of the genetic basis for the cloning of humans, and eventually super-talented individuals. For this he coined the term "clone",[61] though the synonym "clon" (from the Greek word klon meaning "twig") was used in horticulture since the 19th century. He introduced the term in his speech on "Biological Possibilities for the Human Species of the Next Ten Thousand Years" at the Ciba Foundation Symposium on Man and his Future in 1963.[62][63]

Awards and honours

Haldane was elected a Fellow of the Royal Society in 1932.[19] The French Government conferred him its National Order of the Legion of Honour in 1937. In 1952, he received the Darwin Medal from the Royal Society. In 1956, he was awarded the Huxley Memorial Medal of the Anthropological Institute of Great Britain. He received the Feltrinelli Prize from Accademia Nazionale dei Lincei in 1961. He also received an Honorary Doctorate of Science, an Honorary Fellowship at New College, and the Kimber Award of the US National Academy of Sciences. He was awarded the Linnean Society of London's prestigious Darwin–Wallace Medal in 1958.[30]

Quotations

Photograph of a display at the Oxford University Museum of Natural History dedicated to Haldane and his reply when asked to comment on the mind of the Creator

Publications

See also

References

  1. ↑ Pirie, N. W. (1966). "John Burdon Sanderson Haldane. 1892-1964". Biographical Memoirs of Fellows of the Royal Society 12 (0): 218–249. doi:10.1098/rsbm.1966.0010.
  2. ↑ Turelli, M; Orr, HA (1995). "The dominance theory of Haldane's rule". Genetics 140 (1): 389–402. PMC 1206564. PMID 7635302.
  3. ↑ Haldane, J. B. S. (1922). "Sex ratio and unisexual sterility in hybrid animals". Journal of Genetics 12: 101–109. doi:10.1007/BF02983075.
  4. ↑ Yount, Lisa (2003). A to Z of Biologists. New York, NY: Facts on File, Inc. pp. 113–115. ISBN 9781438109176.
  5. ↑ Clarke, Arthur C. (2009). "Foreword". In John Burdon Sanderson Haldane. What I Require From Life: Writings on Science and Life from J.B.S. Haldane. Oxford: Oxford University Press. p. ix. ISBN 9780199237708.
  6. 1 2 Dronamraju, KR (1992). "J.B.S. Haldane (1892-1964): centennial appreciation of a polymath". American Journal of Human Genetics 51 (4): 885–9. PMC 1682816. PMID 1415229.
  7. ↑ Gould, Stephen Jay (2011). The Lying Stones of Marrakech : Penultimate Reflections in Natural History (1st Harvard University Press ed.). Cambridge, Mass.: Belknap Press of Harvard University Press. p. 305. ISBN 9780674061675.
  8. 1 2 3 4 Acott, C. (1999). "JS Haldane, JBS Haldane, L Hill, and A Siebe: A brief resumé of their lives.". South Pacific Underwater Medicine Society Journal 29 (3). ISSN 0813-1988. OCLC 16986801. Retrieved 12 July 2008.
  9. ↑ Hedrick, Larry (1989). "J.B.S. Haldane: A Legacy in Several Worlds". The World & I Online.
  10. ↑ "J. S. Haldane (1860–1936)". Oxfordshire Blue Plaques Board. Retrieved 17 February 2014.
  11. 1 2 Douglas, CG; Haldane, JS; Haldane, JB (1912). "The laws of combination of haemoglobin with carbon monoxide and oxygen". The Journal of Physiology 44 (4): 275–304. doi:10.1113/jphysiol.1912.sp001517. PMC 1512793. PMID 16993128.
  12. ↑ The London Gazette: (Supplement) no. 29172. p. 5081. 25 May 1915. Retrieved 2 April 2015.
  13. ↑ The London Gazette: (Supplement) no. 29172. p. 5079. 25 May 1915. Retrieved 2 April 2015.
  14. ↑ The London Gazette: (Supplement) no. 29399. p. 12410. 10 December 1915. Retrieved 2 April 2015.
  15. ↑ The London Gazette: (Supplement) no. 32445. p. 7036. 2 September 1921. Retrieved 2 April 2015.
  16. 1 2 Cochran, Gregory; Harpending, Henry (10 January 2009). "J.B.S. Haldane". The 10,000 Year Explosion. Retrieved 5 May 2016.
  17. ↑ "Biological Sciences". New College, Oxford. Retrieved 15 April 2016.
  18. 1 2 "John Burdon Sanderson Haldane (1892-1964): Biochemist and geneticist; head of genetics at JIHI, 1927-1937. FRS 1932.". jic.ac.uk.
  19. 1 2 "Full view of record [of Haldane]". UCL Archives. University of California at Berkeley. Retrieved 19 February 2014.
  20. ↑ Jobling MA (2012). "The unexpected always happens". Investigative Genetics 3 (1): 5. doi:10.1186/2041-2223-3-5. PMC 3298498. PMID 22357349.
  21. ↑ Bryson, Bill. "A Short History Of Nearly Everything". 1st. New York: Broadway Books, 2003. at Googlebooks
  22. 1 2 3 4 India After Gandhi: The History of the World's Largest Democracy, Ramachandra Guha, Pan Macmillan, 2008, pp. 769 - 770
  23. 1 2 3 Krishna R. Dronamraju (1987). "On Some Aspects of the Life and Work of John Burdon Sanderson Haldane, F.R.S., in India". Notes and Records of the Royal Society of London 41 (2): 211–237. doi:10.1098/rsnr.1987.0006. JSTOR 531546. PMID 11622022.
  24. ↑ deJong-Lambert, William (2012). The Cold War Politics of Genetic Research: An Introduction to the Lysenko Affair (2012. ed.). Dordrecht: Springer. p. 150. ISBN 9789400728394.
  25. ↑ Majumder PP (1998). "Haldane's Contributions to Biological Research in India" (PDF). Resonance 3 (12): 32–35. doi:10.1007/BF02838095.
  26. ↑ “Haldane on Fast: Insult by USIS Alleged,” Times of India, 19 January 1961; “Protest Fast by Haldane: USIS’s “Anti-Indian Activities,” Times of India, 18 January 1961; “Situation was Misunderstood, Scholars Explain,” Times of India, 20 January 1961; “USIS Explanation does not satisfy Haldane: Protest fast continues,” Times of India, 18 January 1961; “USIS Claim Rejected by Haldane: Protest Fast to Continue,” Times of India, 18 January 1961; “Haldane Not Satisfied with USIS Apology: Fast to Continue,” Free Press Journal, 18 January 1961; “Haldane Goes on Fast In Protest Against U.S. Attitude,” Times of India, 18 January 1961; “Haldane to continue fast: USIS explanation unsatisfactory,” Times of India, 19 January 1961; “Local boy in hunger strike row,” Toronto Star, 20 January 1961; “Haldane, Still on Fast, Loses Weight: U.S.I.S. Act Termed 'Discourteous',” Indian Express, 20 January 1961; “Haldane Slightly Tired on Third Day of Fast,” Times of India, 21 January 1961; “Haldane Fasts for Fourth Consecutive Day,” Globe and Mail, 22 January 1961
  27. ↑ Botting, Gary (1984). "Preface". In Heather Denise Harden and Gary Botting. The Orwellian World of Jehovah's Witnesses. Toronto: University of Toronto Press. p. xvii. ISBN 9780802065452.
  28. ↑ Dronamraju, K. (2010). "J. B. S. Haldane's last years: his life and work in India (1957-1964)". Genetics 185 (1): 5–10. doi:10.1534/genetics.110.116632. PMC 2870975. PMID 20516291.
  29. ↑ Hesketh, Robin (2012). Betrayed by Nature: The War on Cancer. New York (US): Palgrave Macmillan. pp. 237–238. ISBN 978-0-230-34192-0.
  30. 1 2 Mahanti, Subodh. "John Burdon Sanderson Haldane: The Ideal of a Polymath". Vigyan Prasar Science Portal. Retrieved 19 February 2014.
  31. ↑ Murty, K. Krishna (2005). Spice in science. Dehli: Pustak Mahal. p. 68. ISBN 978-81-223-0900-3. Retrieved 1 February 2011.
  32. ↑ Haldane, J. B. S.; Sprunt, A. D.; Haldane, N. M. (1915). "Reduplication in mice (Preliminary Communication)". Journal of Genetics 5 (2): 133–135. doi:10.1007/BF02985370.
  33. ↑ Dronamraju, Krishna R (2012). "Recollections of J.B.S. Haldane, with special reference to Human Genetics in India". Indian Journal of Human Genetics 18 (1): 3. doi:10.4103/0971-6866.96634. PMC 3385175. PMID 22754215.
  34. ↑ Crow, JF (1992). "Centennial: J. B. S. Haldane, 1892-1964". Genetics 130 (1): 1–6. PMC 1204784. PMID 1732155.
  35. ↑ Haldane, JB (1921). "Linkage in poultry". Science 54 (1409): 663. doi:10.1126/science.54.1409.663. PMID 17816160.
  36. ↑ Davies, HW; Haldane, JB; Kennaway, EL (1920). "Experiments on the regulation of the blood's alkalinity: I". The Journal of Physiology 54 (1-2): 32–45. PMC 1405746. PMID 16993473.
  37. ↑ Haldane, JB (1921). "Experiments on the regulation of the blood's alkalinity: II". The Journal of Physiology 55 (3-4): 265–75. PMC 1405425. PMID 16993510.
  38. ↑ Baird, MM; Haldane, JB (1922). "Salt and water elimination in man". The Journal of Physiology 56 (3-4): 259–62. PMC 1405382. PMID 16993567.
  39. ↑ Davies, HW; Haldane, JB; Peskett, GL (1922). "The excretion of chlorides and bicarbonates by the human kidney". The Journal of Physiology 56 (5): 269–74. PMC 1405381. PMID 16993528.
  40. ↑ Briggs, GE; Haldane, JB (1925). "A Note on the Kinetics of Enzyme Action". The Biochemical Journal 19 (2): 338–9. doi:10.1042/bj0190338. PMC 1259181. PMID 16743508.
  41. ↑ Chen, W. W.; Niepel, M.; Sorger, P. K. (2010). "Classic and contemporary approaches to modeling biochemical reactions". Genes & Development 24 (17): 1861–1875. doi:10.1101/gad.1945410. PMC 2932968. PMID 20810646.
  42. ↑ Haldane, JB (1990). "A mathematical theory of natural and artificial selection--I. 1924". Bulletin of Mathematical Biology 52 (1-2): 209–40; discussion 201–7. doi:10.1016/s0092-8240(05)80010-2. PMID 2185859.
  43. ↑ Haldane, JB (1959). "The theory of natural selection today". Nature 183 (4663): 710–3. doi:10.1038/183710a0. PMID 13644170.
  44. ↑ Haldane, J. B. S. (1935). "The rate of spontaneous mutation of a human gene". Journal of Genetics 31 (3): 317–326. doi:10.1007/BF02982403.
  45. ↑ Marvin, Stephen (2012). Dictionary of Scientific Principles. Chicester: John Wiley & Sons. p. 140. ISBN 9781118582244.
  46. ↑ Great Britain: Parliament: House of Commons: Innovation, Universities, Science and Skills Committee (2009). Putting science and engineering at the heart of Government policy : eighth report of session 2008-09 1. London: The Stationery Office. p. 40. ISBN 9780215540348.
  47. 1 2 Lazcano, A. (2010). "Historical development of origins research". Cold Spring Harbor Perspectives in Biology 2 (11): a002089–a002089. doi:10.1101/cshperspect.a002089. PMC 2964185. PMID 20534710.
  48. ↑ Fry, Iris (2000). The Emergence of Life on Earth: A Historical and Scientific Overview. New Brunswick, N.J.: Rutgers University Press. pp. 65–66, 71–74. ISBN 9780813527406.
  49. ↑ Gordon-Smith, Chris. "The Oparin-Haldane Hypothesis". Retrieved 18 February 2014.
  50. ↑ "The Oparin-Haldane Theory of the Origin of Life". Department of Chemistry, University of Oxford. Retrieved 18 February 2014.
  51. ↑ Lazcano, A. (2010). "Historical development of origins research". Cold Spring Harbor Perspectives in Biology 2 (11): a002089–a002089. doi:10.1101/cshperspect.a002089. PMC 2964185. PMID 20534710.
  52. ↑ Sabeti, Pardis C (2008). "Natural selection: uncovering mechanisms of evolutionary adaptation to infectious disease". Nature Education 1 (1): 13.
  53. ↑ Allison, AC (1954). "The distribution of the sickle-cell trait in East Africa and elsewhere, and its apparent relationship to the incidence of subtertian malaria". Transactions of the Royal Society of Tropical Medicine and Hygiene 48 (4): 312–8. doi:10.1016/0035-9203(54)90101-7. PMID 13187561.
  54. ↑ Hedrick, Philip W (2012). "Resistance to malaria in humans: the impact of strong, recent selection". Malaria Journal 11 (1): 349. doi:10.1186/1475-2875-11-349. PMC 3502258. PMID 23088866.
  55. ↑ "Mr. Wells' Apocalypse" by Gerald Heard. The Nineteenth Century, October 1933. Reprinted in The H. G. Wells Scrapbook by Peter Haining. London : New English Library, 1978. ISBN 0450037789 (pp. 108-114).
  56. ↑ Adams, Mark B., "The Quest for Immortality: Visions and Presentiments in Science and Literature", in Post, Stephen G., and Binstock, Robert H., The Fountain of Youth:Cultural, Scientific, and Ethical Perspectives on a Biomedical Goal. Oxford University Press, 2004; ISBN 0195170083 (p. 57-58).
  57. ↑ "An Early Vision of Transhumanism, and the First Proposal of a Hydrogen-Based Renewable Energy Economy". Jeremy Norman & Co., Inc. Retrieved 19 February 2014.
  58. ↑ Hordeski, Michael Frank (2009). Hydrogen & Fuel Cells: Advances in Transportation and Power. Lilburn, GA: The Fairmont Press, Inc. pp. 202–203. ISBN 9780881735628.
  59. ↑ Demirbas, Ayhan (2009). Biohydrogen For Future Engine Fuel Demands (Online-Ausg. ed.). London: Springer London. p. 106. ISBN 9781848825116.
  60. ↑ "Selected Genetic Papers of JBS Haldane", pp. 19–24, New York: Garland, 1990
  61. ↑ Thomas, Isabel (2013). Should scientists pursue cloning?. London: Raintree. p. 5. ISBN 9781406233919.
  62. ↑ Haldane, J.B.S. (1963). "Biological Possibilities for the Human Species in the Next Ten Thousand Years". In Wolstenholme, Gordon. Man and his future. London: J. & A. Churchill. doi:10.1002/9780470715291.ch22. ISBN 9780470714799.
  63. ↑ Haldane, J.B.S. "Biological Possibilities for the Human Species in the Next Ten Thousand Years". World Transhumanist Association. Retrieved 19 February 2014.
  64. ↑ Hutchinson, G. Evelyn (1959). "Homage to Santa Rosalia or Why Are There So Many Kinds of Animals?". The American Naturalist 93 (870): 145–159. doi:10.1086/282070. JSTOR 2458768.
  65. ↑ Stork, Nigel E. (June 1993). "How many species are there?" (PDF). Biodiversity and Conservation 2 (3): 215–232. doi:10.1007/BF00056669. ISSN 0960-3115. Retrieved 25 February 2011.
  66. ↑ Haldane, J.B.S., Possible Worlds: And Other Essays [1927], Chatto and Windus: London, 1932, reprint, p.286. Emphasis in the original.
  67. ↑ Haldane, J.B.S., Possible Worlds: And Other Essays [1927], Chatto and Windus: London, 1932, reprint, p.209.
  68. ↑ Hull, D., Philosophy of Biological Science, Foundations of Philosophy Series, Prentice–Hall, Englewood Cliffs, N. J., 1973.
  69. ↑ Mayr, Ernst (1974) Boston Studies in the Philosophy of Science, Volume XIV, pages 91–117.
  70. ↑ Smith, J.B.S. Haldane ; edited by John Maynard (1985). On being the right size and other essays (Repr ed.). Oxford: Oxford University Press. p. 151. ISBN 9780192860453.
  71. ↑ Haldane, J.B.S. (1963). "[Book review] The Truth About Death: The Chester Beatty Research Institute Serially Abridged Life Tables, England and Wales, 1841-1960" (PDF). Journal of Genetics 58 (3): 464. doi:10.1007/bf02986312.
  72. ↑ Botting, Gary (1984). "Preface". The Orwellian World of Jehovah's Witnesses. p. xvi.
  73. ↑ Majumder, Partha P. (2016-02-01). "A Humanitarian and a Great Indian". Genome Biology and Evolution 8 (2): 467–469. doi:10.1093/gbe/evw012. ISSN 1759-6653. PMC 4779617. PMID 26837547.
  74. ↑ Dugatkin, LA (2007). "Inclusive fitness theory from Darwin to Hamilton". Genetics 176 (3): 1375–80. PMC 1931543. PMID 17641209.
  75. ↑ "Fact and faith,". worldcatlibraries.org.

Further reading

External links

Wikiquote has quotations related to: J. B. S. Haldane
Wikimedia Commons has media related to J. B. S. Haldane.

The biography on the Marxist Writers page has a photograph of Haldane when he was younger.

Academic offices
Preceded by
Julian Huxley		 Fullerian Professor of Physiology
1930 – 1933 		Succeeded by
Grafton Elliot Smith
This article is issued from Wikipedia - version of the Thursday, May 05, 2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.