KIAA0409

Ribosomal RNA processing 8, methyltransferase, homolog (yeast)
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2ZFU​
Identifiers
Symbols	RRP8 ; KIAA0409; NML
External IDs	OMIM: 615818 MGI: 1914251 HomoloGene: 5621 GeneCards: RRP8 Gene
Gene ontology Molecular function • protein binding • S-adenosylmethionine-dependent methyltransferase activity • methylated histone binding • poly(A) RNA binding Cellular component • nucleus • nucleoplasm • chromatin silencing complex • nucleolus • cytoplasm • plasma membrane • rDNA heterochromatin Biological process • chromatin silencing at rDNA • transcription, DNA-templated • rRNA processing • gene expression • chromatin modification • methylation • regulation of gene expression, epigenetic • cellular response to glucose starvation • negative regulation of gene expression, epigenetic • regulation of transcription by glucose • positive regulation of cell cycle arrest • intrinsic apoptotic signaling pathway by p53 class mediator Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23378	101867
Ensembl	ENSG00000132275	ENSMUSG00000030888
UniProt	O43159	Q9DB85
RefSeq (mRNA)	NM_015324	NM_025897
RefSeq (protein)	NP_056139	NP_080173
Location (UCSC)	Chr 11: 6.6 – 6.6 Mb	Chr 7: 105.73 – 105.74 Mb
PubMed search

Ribosomal RNA-processing protein 8 is a protein that in humans is encoded by the RRP8 gene.^[1][2]

References

1. Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Feb 1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477.
2. "Entrez Gene: KIAA0409 KIAA0409".

Further reading

• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
• Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle.". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus.". Mol. Biol. Cell 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
• Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus.". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.