KIAA1199

Cell migration inducing protein, hyaluronan binding
Identifiers
Symbols	CEMIP ; CCSP1; KIAA1199; TMEM2L
External IDs	OMIM: 608366 MGI: 2443629 HomoloGene: 10268 GeneCards: CEMIP Gene
EC number	3.2.1.35
Gene ontology Molecular function • hyalurononglucosaminidase activity • protein binding • hyaluronic acid binding • clathrin heavy chain binding • ER retention sequence binding Cellular component • extracellular region • nucleus • cytoplasm • endoplasmic reticulum • plasma membrane • coated pit • clathrin-coated vesicle membrane Biological process • sensory perception of sound • positive regulation of peptidyl-threonine phosphorylation • hyaluronan catabolic process • positive regulation of cell migration • positive regulation of release of sequestered calcium ion into cytosol • positive regulation of protein targeting to membrane • positive regulation of protein kinase C activity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	57214	80982
Ensembl	ENSG00000103888	ENSMUSG00000052353
UniProt	Q8WUJ3	Q8BI06
RefSeq (mRNA)	NM_001293298	NM_030728
RefSeq (protein)	NP_001280227	NP_109653
Location (UCSC)	Chr 15: 80.78 – 80.95 Mb	Chr 7: 83.93 – 84.09 Mb
PubMed search

Protein KIAA1199 is a protein that in humans is encoded by the KIAA1199 gene.^[1][2][3] The KIAA1199 gene is a recently identified novel gene and one of 1,087 long cDNAs (named KIAA) that encode large proteins (average length of KIAA family member is 872 amino acids).

References

1. Abe S, Usami S, Nakamura Y (Nov 2003). "Mutations in the gene encoding KIAA1199 protein, an inner-ear protein expressed in Deiters' cells and the fibrocytes, as the cause of nonsyndromic hearing loss". J Hum Genet 48 (11): 564–70. doi:10.1007/s10038-003-0079-2. PMID 14577002.
2. Michishita E, Garces G, Barrett JC, Horikawa I (Jul 2006). "Upregulation of the KIAA1199 gene is associated with cellular mortality". Cancer Lett 239 (1): 71–7. doi:10.1016/j.canlet.2005.07.028. PMID 16157444.
3. "Entrez Gene: KIAA1199 KIAA1199".

Further reading

• Nagase T, Ishikawa K, Kikuno R, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.
• Wines ME, Lee L, Katari MS, et al. (2001). "Identification of mesoderm development (mesd) candidate genes by comparative mapping and genome sequence analysis.". Genomics 72 (1): 88–98. doi:10.1006/geno.2000.6466. PMID 11247670.
• Nakayama M, Kikuno R, Ohara O (2003). "Protein–Protein Interactions Between Large Proteins: Two-Hybrid Screening Using a Functionally Classified Library Composed of Long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
• Abe S, Katagiri T, Saito-Hisaminato A, et al. (2003). "Identification of CRYM as a Candidate Responsible for Nonsyndromic Deafness, through cDNA Microarray Analysis of Human Cochlear and Vestibular Tissues". Am. J. Hum. Genet. 72 (1): 73–82. doi:10.1086/345398. PMC 420014. PMID 12471561.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Guo J, Cheng H, Zhao S, Yu L (2006). "GG: a domain involved in phage LTF apparatus and implicated in human MEB and non-syndromic hearing loss diseases". FEBS Lett. 580 (2): 581–4. doi:10.1016/j.febslet.2005.12.076. PMID 16406369.