KIAA1219

Ral GTPase activating protein, beta subunit (non-catalytic)
Identifiers
Symbols	RALGAPB ; KIAA1219; RalGAPbeta
External IDs	MGI: 2444531 HomoloGene: 10666 GeneCards: RALGAPB Gene
Gene ontology Molecular function • GTPase activator activity • protein heterodimerization activity Cellular component • intracellular Biological process • Ral protein signal transduction • regulation of small GTPase mediated signal transduction • regulation of exocyst localization • membrane organization • activation of GTPase activity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	57148	228850
Ensembl	ENSG00000170471	ENSMUSG00000027652
UniProt	Q86X10	Q8BQZ4
RefSeq (mRNA)	NM_001282917	NM_001291137
RefSeq (protein)	NP_001269846	NP_001278066
Location (UCSC)	Chr 20: 38.47 – 38.58 Mb	Chr 2: 158.41 – 158.5 Mb
PubMed search

rotein KIAA1219 is a protein that in humans is encoded by the RALGAPB gene.^[1][2]

References

1. Shirakawa R, Fukai S, Kawato M, Higashi T, Kondo H, Ikeda T, Nakayama E, Okawa K, Nureki O, Kimura T, Kita T, Horiuchi H (Aug 2009). "Tuberous sclerosis tumor suppressor complex-like complexes act as GTPase-activating proteins for Ral GTPases". J Biol Chem 284 (32): 21580–8. doi:10.1074/jbc.M109.012112. PMC 2755882. PMID 19520869.
2. "Entrez Gene: KIAA1219 KIAA1219".

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Gridley S, Chavez JA, Lane WS, Lienhard GE (2006). "Adipocytes contain a novel complex similar to the tuberous sclerosis complex.". Cell. Signal. 18 (10): 1626–32. doi:10.1016/j.cellsig.2006.01.002. PMID 16490346.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
• Nagase T, Ishikawa K, Kikuno R, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.