Knuckle pads

Knuckle pads
Classification and external resources
Specialty	rheumatology
ICD-10	M72.1
ICD-9-CM	728.79
OMIM	149100
DiseasesDB	30724
eMedicine	article/1074379

Knuckle pads (also known as "Heloderma", meaning similar to the skin of the Gila monster lizard for which it is named) are circumscribed, keratotic, fibrous growths over the dorsa of the interphalangeal joints.^[1] Knuckle pads are well-defined, round, plaque-like, fibrous thickening that may develop at any age, and grow to be 10 to 15mm in diameter in the course of a few weeks or months, then go away over time .^[2]:604 Knuckle pads are sometimes associated with Dupuytren's contracture and camptodactyly,^[2]:604 and histologically, the lesions are fibromas.^[2]:605 Knuckle pads are generally non-responsive to treatment, including corticosteroids, and tend to recur after surgery; however, there has been some effectiveness with intralesional fluorouracil.^[3]

See also

• Skin lesion
• List of cutaneous conditions

Notes

1. Freedberg, et al. (2003). Fitzpatrick's Dermatology in General Medicine. (6th ed.). Page 990. McGraw-Hill. ISBN 0-07-138076-0.
2. James, William; Berger, Julia Meakin, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. ISBN 0-7216-2921-0.
3. Weiss, Eduardo; Amini, Sadegh (2007). "A Novel Treatment for Knuckle Pads With Intralesional Fluorouracil". Arch Dermatol. 143(11). Pages 1447-1462. http://archderm.jamanetwork.com/article.aspx?articleid=654437

References

• Guberman D, et al.: Kunckle pads-a forgotten skin condition: report of a case and review of the literature. Cutis 1996;57:241.
• Ly Y, et al.: A novel mutation of keratin 9 in epidermolytic palmoplantar keratoderma combined with knuckle pads. Am J Med Genet 2003;120A:345.
• Peterson CM, et al.: Knuckle pads: does knuckle cracking play an etiologic role? Pediatr Dermatol 2000;17:450.