Lysosomal Pro-X carboxypeptidase

Lysosomal Pro-Xaa carboxypeptidase
Identifiers
EC number 3.4.16.2
CAS number 9075-64-3
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Lysosomal Pro-Xaa carboxypeptidase (EC 3.4.16.2, angiotensinase C, lysosomal carboxypeptidase C, peptidylprolylamino acid carboxypeptidase, aminoacylproline carboxypeptidase, prolyl carboxypeptidase, carboxypeptidase P, proline-specific carboxypeptidase P, PCP) is an enzyme.[1][2] This enzyme catalyses the following chemical reaction

Cleavage of a -Pro-Xaa bond to release a C-terminal amino acid

A lysosomal peptidase active at acidic pH that inactivates angiotensin II. This enzyme is inhibited by diisopropyl fluorophosphate.

References

  1. Walter, R., Simmons, W.H. and Yoshimoto, T. (1980). "Proline specific endo- and exopeptidases". Mol. Cell. Biochem. 30: 111–127. doi:10.1007/bf00227927. PMID 6991912.
  2. Odya, C.E. and Erdös, E.G. (1981). "Human prolylcarboxypeptidase". Methods Enzymol. 80: 460–466. doi:10.1016/s0076-6879(81)80040-7. PMID 7341916.

External links

human prolylcarboxypeptidase entry at OMIM: http://omim.org/entry/176785

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