Metallocarboxypeptidase D

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Metallocarboxypeptidase D (EC 3.4.17.22, carboxypeptidase D (cattle, human, mouse, rat), gp180 (duck)) is an enzyme.^[1]^[2]^[3] This enzyme catalyses the following chemical reaction

Releases C-terminal Arg and Lys from polypeptides

This enzyme is activated by Co²⁺, and inhibited by guanidinoethylmercaptosuccinic acid.

References

↑ Kuroki, K., Eng, F., Ishikawa, T., Turck, C., Harada, F. and Ganem, D. (1995). "gp180, a host cell glycoprotein that binds duck hepatitis B virus particles, is encoded by a member of the carboxypeptidase gene family". J. Biol. Chem. 270: 15022–15028. doi:10.1074/jbc.270.25.15022. PMID 7797483.
↑ Song, L.X. and Fricker, L.D. (1995). "Purification and characterization of carboxypeptidase D, a novel carboxypeptidase E-like enzyme, from bovine pituitary". J. Biol. Chem. 270: 25007–25013. doi:10.1074/jbc.270.42.25007. PMID 7559630.
↑ Song, L.X. and Fricker, L.D. (1996). "Tissue distribution and characterization of soluble and membrane-bound forms of metallocarboxypeptidase D". J. Biol. Chem. 271: 28884–28889. doi:10.1074/jbc.271.46.28884. PMID 8910535.

External links

Metallocarboxypeptidase D at the US National Library of Medicine Medical Subject Headings (MeSH)

Hydrolase: proteases (EC 3.4)

3.4.11-19: Exopeptidase

3.4.11	Aminopeptidase Alanine Arginyl Aspartyl Cystinyl Leucyl Glutamyl Methionyl 1 2 O

3.4.13	Dipeptidase 1 2 3

3.4.14	Dipeptidyl peptidase Cathepsin C Dipeptidyl peptidase-4 Tripeptidyl peptidase Tripeptidyl peptidase I Tripeptidyl peptidase II

3.4.15	Angiotensin-converting enzyme

3.4.16	Serine type carboxypeptidases: Cathepsin A DD-transpeptidase

3.4.17	Metalloexopeptidases Carboxypeptidase A A2 B C E Glutamate II

Other/ungrouped	Metalloexopeptidase

3.4.21-25: Endopeptidase

Other/ungrouped: Amyloid precursor protein secretase

3.4.99: Unknown

Staphylokinase

Proteins: enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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