Morinamide

Morinamide
Systematic (IUPAC) name

N-(morpholin-4-ylmethyl)pyrazine-2-carboxamide
Clinical data
AHFS/Drugs.com	International Drug Names
Identifiers
CAS Number	952-54-5
ATC code	J04AK04 (WHO)
PubChem	CID 70374
ChemSpider	63555
UNII	8CFL28PA3W^Y
KEGG	D07248^Y
Chemical data
Formula	C₁₀H₁₄N₄O₂
Molar mass	222.244 g/mol
SMILES C1COCCN1CNC(=O)C2=NC=CN=C2
InChI InChI=1S/C10H14N4O2/c15-10(9-7-11-1-2-12-9)13-8-14-3-5-16-6-4-14/h1-2,7H,3-6,8H2,(H,13,15) Key:GVTLAVKAVSKBKK-UHFFFAOYSA-N
(verify)

Morinamide (or morphazinamide, or morinamid) is a drug used in the treatment of tuberculosis.^[1]

References

↑ Bonanni G, Ciccariello M, Mancini P, Pace V, Sagliaschi G (1993). "Concomitant ceco-appendicular and urinary tuberculosis. Description of two rare cases: physiopathological and diagnostic remarks". Riv Eur Sci Med Farmacol 15 (3-4): 171–4. PMID 7761665.

Antimycobacterials, including tuberculosis treatment and leprostatic agents (J04)

Nucleic acid inhibitor

Rifamycins/ RNA polymerase inhibitor	Rifampicin^# Rifabutin Rifapentine Rifalazil^§

Antifolates/DSI	Dapsone^# Acedapsone Aldesulfone sodium

ASA	4-Aminosalicylic acid^# (Calcium aminosalicylate Sodium aminosalicylate)

Protein synthesis inhibitor

Aminoglycosides	Amikacin^# Capreomycin^# Kanamycin^# Streptomycin^#

Oxazolidone	Linezolid

Cell envelope antibiotic

Peptidoglycan layer	Alanine analogue: Cycloserine^#

Arabinogalactan layer	Ethylenediamine/arabinosyltransferase inhibitor: Ethambutol^# SQ109^†

Mycolic acid layer	Hydrazides/mycolic acid synth. inhibition: Isoniazid^# Thiocarbamides: Ethionamide^# Prothionamide Thiocarlide

Other/unknown

Combinations

Rifampicin/isoniazid/pyrazinamide

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

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