Terizidone

Terizidone

Systematic (IUPAC) name
4,4'-{1,4-phenylenebis[(E)methylylidenenitrilo]}diisoxazolidin-3-one
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy category	C
Identifiers
CAS Number	25683-71-0
ATC code	J04AK03 (WHO)
PubChem	CID 65720
ChemSpider	59144
UNII	1199LEX5N8
KEGG	D07247
Synonyms	4-[({4-[N-(3-oxo-1,2-oxazolidin-4-yl)carboximidoyl]phenyl}methylidene)amino]-1,2-oxazolidin-3-one
Chemical data
Formula	C14H14N4O4
Molar mass	302.286 g/mol
SMILES O=C3NOCC3/N=C/c2ccc(/C=N/C1C(=O)NOC1)cc2
InChI InChI=1S/C14H14N4O4/c19-13-11(7-21-17-13)15-5-9-1-2-10(4-3-9)6-16-12-8-22-18-14(12)20/h1-6,11-12H,7-8H2,(H,17,19)(H,18,20)/b15-5+,16-6+ Key:ODKYYBOHSVLGNU-IAGONARPSA-N
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Terizidone is a drug used in the treatment of tuberculosis.^[1] Terizidone is used mainly used in multi-drug resistant tuberculosis in conjunction with other second line drugs. It is a derivate of cycloserine and it is a bacteriostatic. ^[2]

References

1. "[Tolerability to terizidone (TZ) in the treatment of pulmonary tuberculosis in dialyzed patients]". Minerva Med. 82 (7-8): 477–81. 1991. PMID 1922892.
2. Rossiter, Dawn (2012). South African Medicines Formulary. Cape Town, South Africa: Health and Medical Publishing Group of the South African Medical Association. pp. 323–325. ISBN 978-1-875098-28-6.