Myxoid liposarcoma

Myxoid liposarcoma
Histopathologic image of myxoid liposarcoma arising in the deep soft tissue of the thigh. H & E stain.
Classification and external resources
ICD-O	8852/3
OMIM	613488
MeSH	D018208

Micrograph of myxoid liposarcoma. H&E stain

A myxoid liposarcoma is a malignant adipose tissue neoplasm^[1] of myxoid appearance histologically.

Myxoid liposarcomas are the second most common type of liposarcoma, representing 30%–40% of all liposarcomas in the limbs; occurring most commonly in the legs, particularly the thigh, followed by the buttocks, retroperitoneum, trunk, ankle, proximal limb girdle, head and neck, and wrist. They occur in the intermuscular fascial planes or deep-seated areas. They present as a large, slow-growing, painless mass.^[2]

They are associated with a fusion between DDIT3 or "CHOP" (at 12q13.1-q13.2) and FUS or "TLS" (at 16p11.2) or EWS (at 22q12.2).^{[3] [4] [5]} The specific translocation of FUS-DDIT3 is t(12;16)(q13;p11).^{[6] [7]}

See also

• Trabectedin
• Lipoma

Further reading

• Myxoid liposarcoma: a rare soft-tissue tumor with a misleading benign appearance
• Efficacy of first-line doxorubicin and ifosfamide in myxoid liposarcoma. 2012

References

1. Myxoid/round cell liposarcoma
2. Sung et al. (2000). "Myxoid Liposarcoma: Appearance at MR Imaging with Histologic Correlation". RadioGraphics 20: 1007–1019. doi:10.1148/radiographics.20.4.g00jl021007.
3. Rabbitts TH, Forster A, Larson R, Nathan P (1993). "Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma". Nat. Genet. 4 (2): 175–80. doi:10.1038/ng0693-175. PMID 7503811.
4. Crozat A, Aman P, Mandahl N, Ron D (1993). "Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma". Nature 363 (6430): 640–4. doi:10.1038/363640a0. PMID 8510758.
5. Forni C, Minuzzo M, Virdis E, et al. (February 2009). "Trabectedin (ET-743) promotes differentiation in myxoid liposarcoma tumors". Mol. Cancer Ther. 8 (2): 449–57. doi:10.1158/1535-7163.MCT-08-0848. PMID 19190116.
6. Aman P, Ron D, Mandahl N, et al. (1993). "Rearrangement of the transcription factor gene CHOP in myxoid liposarcomas with t(12;16)(q13;p11)". Genes Chromosomes Cancer 5 (4): 278–85. doi:10.1002/gcc.2870050403. PMID 1283316.
7. Göransson M, Andersson MK, Forni C, et al. (January 2009). "The myxoid liposarcoma FUS-DDIT3 fusion oncoprotein deregulates NF-kappaB target genes by interaction with NFKBIZ". Oncogene 28 (2): 270–8. doi:10.1038/onc.2008.378. PMID 18850010.