Nucleoporin 107

Nucleoporin 107kDa
Rendering based on PDB 3CQC​.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3CQC​, 3CQG​, 3I4R​
Identifiers
Symbols	NUP107 ; NUP84
External IDs	OMIM: 607617 MGI: 2143854 HomoloGene: 5555 GeneCards: NUP107 Gene
Gene ontology Molecular function • nucleocytoplasmic transporter activity • protein binding • structural constituent of nuclear pore Cellular component • kinetochore • condensed chromosome kinetochore • nuclear envelope • nuclear pore • nucleoplasm • centrosome • cytosol • membrane • nuclear pore outer ring • nuclear membrane • nuclear periphery Biological process • mitotic cell cycle • carbohydrate metabolic process • mRNA export from nucleus • mitotic nuclear envelope disassembly • small GTPase mediated signal transduction • hexose transport • gene expression • regulation of glucose transport • protein transport • glucose transport • viral process • protein sumoylation • viral life cycle • viral transcription • cytokine-mediated signaling pathway • cellular response to heat • post-translational protein modification • cellular protein metabolic process • small molecule metabolic process • nuclear pore complex assembly • transmembrane transport • regulation of cellular response to heat Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	57122	103468
Ensembl	ENSG00000111581	ENSMUSG00000052798
UniProt	P57740	Q8BH74
RefSeq (mRNA)	NM_020401	NM_134010
RefSeq (protein)	NP_065134	NP_598771
Location (UCSC)	Chr 12: 68.69 – 68.75 Mb	Chr 10: 117.75 – 117.79 Mb
PubMed search

Nucleoporin 107 (Nup107) is a protein that in humans is encoded by the NUP107 gene.^[1][2][3]

Function

This gene encodes a member of the nucleoporin family. The protein is localized to the nuclear rim and is an essential component of the nuclear pore complex (NPC). All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.^[3]

Interactions

NUP107 has been shown to interact with NUP133.^[4][5]

References

1. Boehmer T, Enninga J, Dales S, Blobel G, Zhong H (Feb 2003). "Depletion of a single nucleoporin, Nup107, prevents the assembly of a subset of nucleoporins into the nuclear pore complex". Proceedings of the National Academy of Sciences of the United States of America 100 (3): 981–5. doi:10.1073/pnas.252749899. PMC 298712. PMID 12552102.
2. Walther TC, Alves A, Pickersgill H, Loïodice I, Hetzer M, Galy V, Hülsmann BB, Köcher T, Wilm M, Allen T, Mattaj IW, Doye V (Apr 2003). "The conserved Nup107-160 complex is critical for nuclear pore complex assembly". Cell 113 (2): 195–206. doi:10.1016/S0092-8674(03)00235-6. PMID 12705868.
3. "Entrez Gene: NUP107 nucleoporin 107kDa".
4. Loïodice I, Alves A, Rabut G, Van Overbeek M, Ellenberg J, Sibarita JB, Doye V (Jul 2004). "The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis". Molecular Biology of the Cell 15 (7): 3333–44. doi:10.1091/mbc.E03-12-0878. PMC 452587. PMID 15146057.
5. Belgareh N, Rabut G, Baï SW, van Overbeek M, Beaudouin J, Daigle N, Zatsepina OV, Pasteau F, Labas V, Fromont-Racine M, Ellenberg J, Doye V (Sep 2001). "An evolutionarily conserved NPC subcomplex, which redistributes in part to kinetochores in mammalian cells". The Journal of Cell Biology 154 (6): 1147–60. doi:10.1083/jcb.200101081. PMC 2150808. PMID 11564755.

Further reading

• Bastos R, Ribas de Pouplana L, Enarson M, Bodoor K, Burke B (Jun 1997). "Nup84, a novel nucleoporin that is associated with CAN/Nup214 on the cytoplasmic face of the nuclear pore complex". The Journal of Cell Biology 137 (5): 989–1000. doi:10.1083/jcb.137.5.989. PMC 2136229. PMID 9166401.
• Belgareh N, Rabut G, Baï SW, van Overbeek M, Beaudouin J, Daigle N, Zatsepina OV, Pasteau F, Labas V, Fromont-Racine M, Ellenberg J, Doye V (Sep 2001). "An evolutionarily conserved NPC subcomplex, which redistributes in part to kinetochores in mammalian cells". The Journal of Cell Biology 154 (6): 1147–60. doi:10.1083/jcb.200101081. PMC 2150808. PMID 11564755.
• Vasu S, Shah S, Orjalo A, Park M, Fischer WH, Forbes DJ (Oct 2001). "Novel vertebrate nucleoporins Nup133 and Nup160 play a role in mRNA export". The Journal of Cell Biology 155 (3): 339–54. doi:10.1083/jcb.200108007. PMC 2150853. PMID 11684705.
• Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Walther TC, Askjaer P, Gentzel M, Habermann A, Griffiths G, Wilm M, Mattaj IW, Hetzer M (Aug 2003). "RanGTP mediates nuclear pore complex assembly". Nature 424 (6949): 689–94. doi:10.1038/nature01898. PMID 12894213.
• Loïodice I, Alves A, Rabut G, Van Overbeek M, Ellenberg J, Sibarita JB, Doye V (Jul 2004). "The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis". Molecular Biology of the Cell 15 (7): 3333–44. doi:10.1091/mbc.E03-12-0878. PMC 452587. PMID 15146057.
• Krull S, Thyberg J, Björkroth B, Rackwitz HR, Cordes VC (Sep 2004). "Nucleoporins as components of the nuclear pore complex core structure and Tpr as the architectural element of the nuclear basket". Molecular Biology of the Cell 15 (9): 4261–77. doi:10.1091/mbc.E04-03-0165. PMC 515357. PMID 15229283.
• Berke IC, Boehmer T, Blobel G, Schwartz TU (Nov 2004). "Structural and functional analysis of Nup133 domains reveals modular building blocks of the nuclear pore complex". The Journal of Cell Biology 167 (4): 591–7. doi:10.1083/jcb.200408109. PMC 2172596. PMID 15557116.
• Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (Apr 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
• Orjalo AV, Arnaoutov A, Shen Z, Boyarchuk Y, Zeitlin SG, Fontoura B, Briggs S, Dasso M, Forbes DJ (Sep 2006). "The Nup107-160 nucleoporin complex is required for correct bipolar spindle assembly". Molecular Biology of the Cell 17 (9): 3806–18. doi:10.1091/mbc.E05-11-1061. PMC 1593160. PMID 16807356.
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (Oct 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Glavy JS, Krutchinsky AN, Cristea IM, Berke IC, Boehmer T, Blobel G, Chait BT (Mar 2007). "Cell-cycle-dependent phosphorylation of the nuclear pore Nup107-160 subcomplex". Proceedings of the National Academy of Sciences of the United States of America 104 (10): 3811–6. doi:10.1073/pnas.0700058104. PMC 1820666. PMID 17360435.
• Zuccolo M, Alves A, Galy V, Bolhy S, Formstecher E, Racine V, Sibarita JB, Fukagawa T, Shiekhattar R, Yen T, Doye V (Apr 2007). "The human Nup107-160 nuclear pore subcomplex contributes to proper kinetochore functions". The EMBO Journal 26 (7): 1853–64. doi:10.1038/sj.emboj.7601642. PMC 1847668. PMID 17363900.
• Boehmer T, Schwartz TU (Sep 2007). "Purification, crystallization and preliminary X-ray analysis of a Nup107-Nup133 heterodimeric nucleoporin complex". Acta Crystallographica. Section F, Structural Biology and Crystallization Communications 63 (Pt 9): 816–8. doi:10.1107/S1744309107040523. PMC 2376328. PMID 17768364.