Oxetacaine

Oxetacaine

Systematic (IUPAC) name
2,2'-(2-hydroxyethylimino)bis [N-(1,1-dimethyl-2- phenylethyl)-N-methylacetamide]
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of administration	Oral, topical
Pharmacokinetic data
Biological half-life	1 hour
Identifiers
CAS Number	126-27-2
ATC code	C05AD06 (WHO)
PubChem	CID 4621
ChemSpider	4460
UNII	IP8QT76V17
KEGG	D01152
ChEMBL	CHEMBL127592
Chemical data
Formula	C28H41N3O3
Molar mass	467.643 g/mol
SMILES O=C(N(C(C)(C)Cc1ccccc1)C)CN(CCO)CC(=O)N(C(Cc2ccccc2)(C)C)C
InChI InChI=1S/C28H41N3O3/c1-27(2,19-23-13-9-7-10-14-23)29(5)25(33)21-31(17-18-32)22-26(34)30(6)28(3,4)20-24-15-11-8-12-16-24/h7-16,32H,17-22H2,1-6H3 Key:FTLDJPRFCGDUFH-UHFFFAOYSA-N
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Oxetacaine (INN, also known as oxethazaine) is a potent local anesthetic. It is administered orally (usually in combination with an antacid) for the relief of pain associated with peptic ulcer disease or esophagitis. It is also used topically in the management of hemorrhoid pain. Oral oxetacaine preparations are available in several countries, including India, South Africa, Japan and Brazil, but not the United States.

Unlike most local anesthetics, oxetacaine does not break down under strongly acidic conditions.^[1]

References

1. Seifter J, Glassman JM, Hudyma GM (1962). "Oxethazaine and related congeners: a series of highly potent local anesthetics". Proc Soc Exp Biol Med 109: 664–8. doi:10.3181/00379727-109-27300. PMID 13910333.

External links

• Strocain Prescribing information from Eisai Co.