PICK1

Protein interacting with PRKCA 1
PDB rendering based on 2gzv.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2GZV​
Identifiers
Symbols	PICK1 ; PICK; PRKCABP
External IDs	OMIM: 605926 MGI: 894645 HomoloGene: 7470 GeneCards: PICK1 Gene
Gene ontology Molecular function • G-protein coupled receptor binding • protein kinase C binding • receptor binding • protein binding • protein C-terminus binding • ATPase activity • enzyme binding • protein domain specific binding • identical protein binding • metal ion binding • actin filament binding • Arp2/3 complex binding Cellular component • cytoplasm • mitochondrion • Golgi apparatus • cytoskeleton • plasma membrane • cell junction • endocytic vesicle membrane • presynaptic membrane • neuron projection • synapse • postsynaptic membrane • perinuclear region of cytoplasm • neuronal postsynaptic density Biological process • positive regulation of receptor internalization • protein phosphorylation • protein targeting • retrograde vesicle-mediated transport, Golgi to ER • protein kinase C-activating G-protein coupled receptor signaling pathway • synaptic transmission • monoamine transport • glial cell development • regulation of Arp2/3 complex-mediated actin nucleation • negative regulation of Arp2/3 complex-mediated actin nucleation • cellular response to decreased oxygen levels • cellular response to glucose starvation • DNA methylation involved in embryo development • DNA methylation involved in gamete generation • receptor clustering • neuronal ion channel clustering • regulation of synaptic plasticity • long term synaptic depression • dendritic spine organization • dendritic spine maintenance Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9463	18693
Ensembl	ENSG00000100151	ENSMUSG00000068206
UniProt	Q9NRD5	Q62083
RefSeq (mRNA)	NM_001039583	NM_001045558
RefSeq (protein)	NP_001034672	NP_001039023
Location (UCSC)	Chr 22: 38.06 – 38.08 Mb	Chr 15: 79.23 – 79.26 Mb
PubMed search

PRKCA-binding protein is a protein that in humans is encoded by the PICK1 gene.^[1][2]

Function

The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene.^[3]

Interactions

PICK1 has been shown to interact with:

• ACCN2,^[4][5]
• BNC1,^[5]
• Dopamine transporter,^[6]
• GRIA2,^[7]
• GRIA3,^[7]
• GRIA4,^[7]
• GRIK1,^[8]
• GRIK2,^[8]
• GRIK3,^[7]
• HER2/neu,^[9]
• Metabotropic glutamate receptor 3,^[7] and
• Metabotropic glutamate receptor 7.^[10]

References

1. Dev KK, Nishimune A, Henley JM, Nakanishi S (July 1999). "The protein kinase C alpha binding protein PICK1 interacts with short but not long form alternative splice variants of AMPA receptor subunits". Neuropharmacology 38 (5): 635–44. doi:10.1016/S0028-3908(98)00230-5. PMID 10340301.
2. Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (December 1999). "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
3. "Entrez Gene: PICK1 protein interacting with PRKCA 1".
4. Leonard AS, Yermolaieva O, Hruska-Hageman A, Askwith CC, Price MP, Wemmie JA, Welsh MJ (February 2003). "cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1". Proc. Natl. Acad. Sci. U.S.A. 100 (4): 2029–34. doi:10.1073/pnas.252782799. PMC 149953. PMID 12578970.
5. Hruska-Hageman AM, Wemmie JA, Price MP, Welsh MJ (February 2002). "Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel)". Biochem. J. 361 (Pt 3): 443–50. doi:10.1042/0264-6021:3610443. PMC 1222326. PMID 11802773.
6. Torres GE, Yao WD, Mohn AR, Quan H, Kim KM, Levey AI, Staudinger J, Caron MG (April 2001). "Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1". Neuron 30 (1): 121–34. doi:10.1016/s0896-6273(01)00267-7. PMID 11343649.
7. Hirbec H, Perestenko O, Nishimune A, Meyer G, Nakanishi S, Henley JM, Dev KK (May 2002). "The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs". J. Biol. Chem. 277 (18): 15221–4. doi:10.1074/jbc.C200112200. PMID 11891216.
8. Hirbec H, Francis JC, Lauri SE, Braithwaite SP, Coussen F, Mulle C, Dev KK, Coutinho V, Meyer G, Isaac JT, Collingridge GL, Henley JM, Couthino V (February 2003). "Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIP". Neuron 37 (4): 625–38. doi:10.1016/s0896-6273(02)01191-1. PMC 3314502. PMID 12597860.
9. Jaulin-Bastard F, Saito H, Le Bivic A, Ollendorff V, Marchetto S, Birnbaum D, Borg JP (May 2001). "The ERBB2/HER2 receptor differentially interacts with ERBIN and PICK1 PSD-95/DLG/ZO-1 domain proteins". J. Biol. Chem. 276 (18): 15256–63. doi:10.1074/jbc.M010032200. PMID 11278603.
10. Dev KK, Nakajima Y, Kitano J, Braithwaite SP, Henley JM, Nakanishi S (October 2000). "PICK1 interacts with and regulates PKC phosphorylation of mGLUR7". J. Neurosci. 20 (19): 7252–7. PMID 11007882.

Further reading

• Collingridge GL, Isaac JT (2003). "Functional roles of protein interactions with AMPA and kainate receptors". Neurosci. Res. 47 (1): 3–15. doi:10.1016/S0168-0102(03)00160-3. PMID 12941441.
• Xu J, Xia J (2006). "Structure and function of PICK1". Neurosignals 15 (4): 190–201. doi:10.1159/000098482. PMID 17215589.
• Staudinger J, Zhou J, Burgess R, Elledge SJ, Olson EN (1995). "PICK1: a perinuclear binding protein and substrate for protein kinase C isolated by the yeast two-hybrid system". J. Cell Biol. 128 (3): 263–71. doi:10.1083/jcb.128.3.263. PMC 2120344. PMID 7844141.
• Staudinger J, Lu J, Olson EN (1998). "Specific interaction of the PDZ domain protein PICK1 with the COOH terminus of protein kinase C-alpha". J. Biol. Chem. 272 (51): 32019–24. doi:10.1074/jbc.272.51.32019. PMID 9405395.
• Xia J, Zhang X, Staudinger J, Huganir RL (1999). "Clustering of AMPA receptors by the synaptic PDZ domain-containing protein PICK1". Neuron 22 (1): 179–87. doi:10.1016/S0896-6273(00)80689-3. PMID 10027300.
• Torres R, Firestein BL, Dong H, Staudinger J, Olson EN, Huganir RL, Bredt DS, Gale NW, Yancopoulos GD (1999). "PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands". Neuron 21 (6): 1453–63. doi:10.1016/S0896-6273(00)80663-7. PMID 9883737.
• Takeya R, Takeshige K, Sumimoto H (2000). "Interaction of the PDZ domain of human PICK1 with class I ADP-ribosylation factors". Biochem. Biophys. Res. Commun. 267 (1): 149–55. doi:10.1006/bbrc.1999.1932. PMID 10623590.
• Cowan CA, Yokoyama N, Bianchi LM, Henkemeyer M, Fritzsch B (2000). "EphB2 guides axons at the midline and is necessary for normal vestibular function". Neuron 26 (2): 417–30. doi:10.1016/S0896-6273(00)81174-5. PMID 10839360.
• Dev KK, Nakajima Y, Kitano J, Braithwaite SP, Henley JM, Nakanishi S (2001). "PICK1 interacts with and regulates PKC phosphorylation of mGLUR7". J. Neurosci. 20 (19): 7252–7. PMID 11007882.
• Lin WJ, Chang YF, Wang WL, Huang CY (2001). "Mitogen-stimulated TIS21 protein interacts with a protein-kinase-Calpha-binding protein rPICK1". Biochem. J. 354 (Pt 3): 635–43. doi:10.1042/0264-6021:3540635. PMC 1221695. PMID 11237868.
• Jaulin-Bastard F, Saito H, Le Bivic A, Ollendorff V, Marchetto S, Birnbaum D, Borg JP (2001). "The ERBB2/HER2 receptor differentially interacts with ERBIN and PICK1 PSD-95/DLG/ZO-1 domain proteins". J. Biol. Chem. 276 (18): 15256–63. doi:10.1074/jbc.M010032200. PMID 11278603.
• Torres GE, Yao WD, Mohn AR, Quan H, Kim KM, Levey AI, Staudinger J, Caron MG (2001). "Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1". Neuron 30 (1): 121–34. doi:10.1016/S0896-6273(01)00267-7. PMID 11343649.
• Lin SH, Arai AC, Wang Z, Nothacker HP, Civelli O (2001). "The carboxyl terminus of the prolactin-releasing peptide receptor interacts with PDZ domain proteins involved in alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor clustering". Mol. Pharmacol. 60 (5): 916–23. PMID 11641419.
• Duggan A, Garcia-Anoveros J, Corey DP (2002). "The PDZ domain protein PICK1 and the sodium channel BNaC1 interact and localize at mechanosensory terminals of dorsal root ganglion neurons and dendrites of central neurons". J. Biol. Chem. 277 (7): 5203–8. doi:10.1074/jbc.M104748200. PMID 11739374.
• Hruska-Hageman AM, Wemmie JA, Price MP, Welsh MJ (2002). "Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel)". Biochem. J. 361 (Pt 3): 443–50. doi:10.1042/0264-6021:3610443. PMC 1222326. PMID 11802773.
• Hirbec H, Perestenko O, Nishimune A, Meyer G, Nakanishi S, Henley JM, Dev KK (2002). "The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs". J. Biol. Chem. 277 (18): 15221–4. doi:10.1074/jbc.C200112200. PMID 11891216.
• Perroy J, El Far O, Bertaso F, Pin JP, Betz H, Bockaert J, Fagni L (2002). "PICK1 is required for the control of synaptic transmission by the metabotropic glutamate receptor 7". EMBO J. 21 (12): 2990–9. doi:10.1093/emboj/cdf313. PMC 126066. PMID 12065412.
• Jansen AM, Nässel DR, Madsen KL, Jung AG, Gether U, Kjaerulff O (2009). "PICK1 expression in the Drosophila nervous system primarily occurs in the nervous system". J. Comp. Neurol. 517 (3): 313–322. doi:10.1002/cne.22155. PMID 19757495.

External links

• Genecards
• MGI