Peptidyl-dipeptidase B

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Peptidyl-dipeptidase B (EC 3.4.15.4, dipeptidyl carboxyhydrolase, atriopeptin convertase, atrial di-(tri)peptidyl carboxyhydrolase, peptidyldipeptidase B, atrial dipeptidyl carboxyhydrolase, atrial peptide convertase) is an enzyme.^[1]^[2]^[3]^[4] It catalyses the following chemical reaction

Release of a C-terminal dipeptide or exceptionally a tripeptide

This membrane-bound, zinc metallopeptidase is located in mammalian atrial myocytes.

References

↑ Harris, R.B. and Wilson, I.B. (1984). "Atrial tissue contains a metallo dipeptidyl carboxyhydrolase not present in ventricular tissue: partial purification and characterization". Arch. Biochem. Biophys. 233: 667–675. doi:10.1016/0003-9861(84)90493-4. PMID 6385859.
↑ Harris, R.B. and Wilson, I.B. (1985). "Conversion of atriopeptin II to atriopeptin I by atrial dipeptidyl carboxy hydrolase". Peptides (Fayetteville) 6: 393–396. doi:10.1016/0196-9781(85)90102-0. PMID 2999723.
↑ Soler, D.F. and Harris, R.B. (1988). "Continuous fluorogenic substrates for atrial dipeptidyl carboxyhydrolase. Importance of Ser in the P1 position". Int. J. Peptide Protein Res. 32: 35–40. PMID 3146555.
↑ Soler, D.F. and Harris, R.B. (1989). "Atrial dipeptidyl carboxyhydrolase is a zinc-metallo proteinase which possesses tripeptidyl carboxyhydrolase activity". Peptides (Fayetteville) 10: 63–68. doi:10.1016/0196-9781(89)90077-6. PMID 2501770.

External links

Peptidyl-dipeptidase B at the US National Library of Medicine Medical Subject Headings (MeSH)

Hydrolase: proteases (EC 3.4)

3.4.11-19: Exopeptidase

3.4.11	Aminopeptidase Alanine Arginyl Aspartyl Cystinyl Leucyl Glutamyl Methionyl 1 2 O

3.4.13	Dipeptidase 1 2 3

3.4.14	Dipeptidyl peptidase Cathepsin C Dipeptidyl peptidase-4 Tripeptidyl peptidase Tripeptidyl peptidase I Tripeptidyl peptidase II

3.4.15	Angiotensin-converting enzyme

3.4.16	Serine type carboxypeptidases: Cathepsin A DD-transpeptidase

3.4.17	Metalloexopeptidases Carboxypeptidase A A2 B C E Glutamate II

Other/ungrouped	Metalloexopeptidase

3.4.21-25: Endopeptidase

Other/ungrouped: Amyloid precursor protein secretase

3.4.99: Unknown

Staphylokinase

Proteins: enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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