Peptidyl-glycinamidase

Identifiers

Databases

IntEnz

IntEnz view

PDB structures

Search
PMC	articles
PubMed	articles
NCBI	proteins

Peptidyl-glycinamidase (EC 3.4.19.2, carboxyamidase, peptidyl carboxy-amidase, peptidyl-aminoacylamidase, carboxamidopeptidase, peptidyl amino acid amide hydrolase) is an enzyme.^[1]^[2]^[3] This enzyme catalyses the following chemical reaction

Cleavage of C-terminal glycinamide from polypeptides

This enzyme inactivates vasopressin and oxytocin by splitting off glycinamide.

References

↑ Fruhaufová, L., Suska-Brezezinska, E., Barth, T. and Rychlik, I. (1973). "Rat liver enzyme inactivating oxytocin and its deamino-carba analogues". Coll. Czech. Chem. Commun. 38: 2793–2798. doi:10.1135/cccc19732793.
↑ Nardacci, N.J., Mukhopadhyay, S. and Campbell, B.J. (1975). "Partial purification and characterization of the antidiuretic hormone in toad bladder". Biochim. Biophys. Acta 377: 146–157. doi:10.1016/0005-2744(75)90295-8. PMID 1122284.
↑ Simmons, W.H. and Walter, R. (1980). "Carboxamidopeptidase: purificaction and characterization of a neurohypophyseal hormone inactivating peptidase from toad skin". Biochemistry 19: 39–48. doi:10.1021/bi00542a007. PMID 6766314.

External links

Peptidyl-glycinamidase at the US National Library of Medicine Medical Subject Headings (MeSH)

Hydrolase: proteases (EC 3.4)

3.4.11-19: Exopeptidase

3.4.11	Aminopeptidase Alanine Arginyl Aspartyl Cystinyl Leucyl Glutamyl Methionyl 1 2 O

3.4.13	Dipeptidase 1 2 3

3.4.14	Dipeptidyl peptidase Cathepsin C Dipeptidyl peptidase-4 Tripeptidyl peptidase Tripeptidyl peptidase I Tripeptidyl peptidase II

3.4.15	Angiotensin-converting enzyme

3.4.16	Serine type carboxypeptidases: Cathepsin A DD-transpeptidase

3.4.17	Metalloexopeptidases Carboxypeptidase A A2 B C E Glutamate II

Other/ungrouped	Metalloexopeptidase

3.4.21-25: Endopeptidase

Other/ungrouped: Amyloid precursor protein secretase

3.4.99: Unknown

Staphylokinase

Proteins: enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

This article is issued from Wikipedia - version of the Tuesday, January 26, 2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.