Piebaldism

Piebaldism
Classification and external resources
Specialty endocrinology
ICD-10 E70.3 (ILDS E70.350)
ICD-9-CM 709.09
OMIM 172800
DiseasesDB 29295
eMedicine derm/689
MeSH D016116
Orphanet 2884

Piebaldism is a rare autosomal dominant disorder of melanocyte development.[1]:867 Common characteristics include a congenital white forelock, scattered normal pigmented and hypopigmented macules and a triangular shaped depigmented patch on the forehead. There is nevertheless great variation in the degree and pattern of presentation, even within affected families. In some cases, piebaldism occurs together with severe developmental problems, as in Waardenburg syndrome and Hirschsprung's disease. It has been documented to occur in all races; early photographers captured many images of African piebalds used as a form of amusement, and George Catlin is believed to have painted several portraits of Native Americans of the Mandan tribe who were affected by piebaldism.[2] Piebaldism is found in nearly every species of mammal. It is very common in mice, rabbits, dogs, sheep, deer, cattle and horses—where selective breeding has increased the incidence of the mutation-, but occurs among chimpanzees and other primates only as rarely as among humans. Piebaldism is completely unrelated to acquired or infectious conditions such as vitiligo or poliosis.

"Pie" is a word for multi-colored and "bald" is related to a root word for "skin." Although piebaldism may visually appear to be partial albinism, it is a fundamentally different condition. The vision problems associated with albinism are not usually present as eye pigmentation is normal. Piebaldism differs from albinism in that the affected cells maintain the ability to produce pigment but have that specific function turned off. In albinism the cells lack the ability to produce pigment altogether. Human piebaldism has been observed to be associated with a very wide range and varying degrees of endocrine disorders, and is occasionally found together with heterochromia of the irises, congenital deafness, or incomplete gastrointestinal tract development, possibly all with the common cause of premature cutting off of human fetal growth hormone during gestation. Piebaldism is a kind of neurocristopathy, involving defects of various neural crest cell lineages that include melanocytes, but also involving many other tissues derived from the neural crest. Oncogenic factors, including mistranscription, are hypothesized to be related to the degree of phenotypic variation among affected individuals.

This is an autosomal dominant[3] hereditary condition, which tends to produce high rates of inheritance and long chains of generational transmission. All who inherit the gene have at some time in life evidence of piebald hypopigmentation of the hair or skin, most likely both. Historically, persons with extensive piebaldism have experienced abuse of the sort still suffered in the present by albinos, especially in Africa. This has ranged from display of unclothed African piebalds in "freak" shows and post cards of the early twentieth century to the forcing of piebalds (as in the case of albinos) to work long hours exposed to the sun (producing high rates of lethal skin cancers), to the use of piebald humans, including children, in risky medical experiments. The National Organization of Albinism and Hypopigmentation, as well as organizations such as Under the Same Sun, work to promote awareness of all forms of cutaneous variation and their medical implications, and to highlight human rights issues, especially the plight of albinos subject to extreme persecution in parts of Africa.[4]

Piebaldism may be associated with the genes KIT[5] or SNAI2.[6]

See also

References

  1. ↑ James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. ISBN 0-7216-2921-0.
  2. ↑ Victor A. McKusick, Mendelian Inheritance in Man: A Catalog of Human Genes and Genetic Disorders, Volume 1 (Johns Hopkins University Press, 1428-1429)
  3. ↑ MedlinePlus Encyclopedia Autosomal dominant
  4. ↑ Spritz, RA (1997). "Piebaldism, Waardenburg syndrome, and related disorders of melanocyte development". Seminars in Cutaneous Medicine and Surgery 16 (1): 15–23. doi:10.1016/s1085-5629(97)80031-4. PMID 9125761.
  5. ↑ Giebel, L. B.; Spritz, R. A. (1991). "Mutation of the KIT (mast/stem cell growth factor receptor) protooncogene in human piebaldism". Proceedings of the National Academy of Sciences 88 (19): 8696–9. Bibcode:1991PNAS...88.8696G. doi:10.1073/pnas.88.19.8696. JSTOR 2358007. PMC 52576. PMID 1717985.
  6. ↑ Sánchez-Martín M, Pérez-Losada J, Rodríguez-García A, et al. (October 2003). "Deletion of the SLUG (SNAI2) gene results in human piebaldism". Am. J. Med. Genet. A 122A (2): 125–32. doi:10.1002/ajmg.a.20345. PMID 12955764.

External links

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