Pirolazamide

Pirolazamide
Systematic (IUPAC) name

4-(hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-2,2-diphenylbutanamide
Identifiers
CAS Number	39186-49-7^N
ATC code	none
PubChem	CID 71442
ChemSpider	64526^Y
UNII	GQN5BVM24W^Y
KEGG	D05509^Y
Chemical data
Formula	C₂₃H₂₉N₃O
Molar mass	363.502 g/mol
SMILES O=C(N)C(c1ccccc1)(c2ccccc2)CCN4CC3N(CCC3)CC4
InChI InChI=1S/C23H29N3O/c24-22(27)23(19-8-3-1-4-9-19,20-10-5-2-6-11-20)13-15-25-16-17-26-14-7-12-21(26)18-25/h1-6,8-11,21H,7,12-18H2,(H2,24,27)^Y Key:SEINJQWGYXAADT-UHFFFAOYSA-N^Y
^NY (what is this?) (verify)

Pirolazamide (SC-26,438) is an antiarrhythmic agent that was never marked.^[1]

References

↑ David J. Triggle (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. ISBN 0-412-46630-9.

Antiarrhythmic agents (C01B)

Channel blockers

class I
(Na⁺ channel blockers)

class Ia (Phase 0→ and Phase 3→)	Ajmaline Disopyramide Lorajmine Prajmaline Procainamide^# Quinidine^# Sparteine

class Ib (Phase 3←)	IV (Lidocaine^#) enteral (Aprindine Mexiletine Tocainide)

class Ic (Phase 0→)	Encainide^‡ Ethacizine Flecainide Indecainide^‡ Lorcainide Moracizine^‡ Propafenone

class III
(Phase 3→, K⁺ channel blockers)

class IV
(Phase 4→, Ca²⁺ channel blockers)

Diltiazem
Verapamil^#

Receptor agonists
and antagonists

class II (Phase 4→, β blockers)	Nadolol Pindolol Propranolol cardioselective (Acebutolol Atenolol Esmolol Metoprolol)

A₁ agonist	Adenosine Benzodiazepines Barbiturates

M₂	muscarinic antagonist: Atropine Disopyramide Quinidine muscarinic agonist: Digoxin

α receptors	Amiodarone Bretylium Quinidine Verapamil

Ion transporters

Na⁺/ K⁺-ATPase	Digoxin

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

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