Potassium channel RNA editing signal

Potassium channel RNA editing signal
Predicted secondary structure and sequence conservation of K_chan_RES
Identifiers
Symbol K_chan_RES
Rfam RF00485
Other data
RNA type Cis-reg
Domain(s) Eukaryota
SO 0000233

The potassium channel RNA editing signal is an RNA element found in human Kv1.1 and its homologues which directs the efficient modification of an adenosine to inosine by an adenosine deaminase acting on RNA (ADAR). The ADAR modification causes an isoleucine/valine recoding event which lies in the ion-conducting pore of the potassium channel. It is thought that this editing event targets the process of fast inactivation and allows a more rapid recovery from inactivation at negative potentials.[1]

References

  1. Bhalla, T; Rosenthal JJ; Holmgren M; Reenan R (2004). "Control of human potassium channel inactivation by editing of a small mRNA hairpin". Nat Struct Mol Biol 11 (10): 950956. doi:10.1038/nsmb825. PMID 15361858.

External links

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