Prolyl aminopeptidase

Identifiers

Databases

IntEnz

IntEnz view

PDB structures

Search
PMC	articles
PubMed	articles
NCBI	proteins

Prolyl aminopeptidase (EC 3.4.11.5, proline aminopeptidase, Pro-X aminopeptidase, cytosol aminopeptidase V, proline iminopeptidase) is an enzyme.^[1]^[2]^[3] This enzyme catalyses the following chemical reaction

Release of N-terminal proline from a peptide

This enzyme requires Mn²⁺ ion to function.

References

↑ Sarid, S., Berger, A. and Katchalski, E. (1962). "Proline iminopeptidase. II. Purification and comparison with iminopeptidase (prolinase)". J. Biol. Chem. 237: 2207–2212. PMID 14497218.
↑ Nordwig, A. and Mayer, H. (1973). "The cleavage of prolyl peptidases by kidney peptidases". Hoppe-Seyler's Z. Physiol. Chem. 354: 380–383. doi:10.1515/bchm2.1973.354.1.380. PMID 4803482.
↑ Turzynski, A. and Mentlein, R. (1990). "Prolyl aminopeptidase from rat brain and kidney. Action on peptides and identification as leucyl aminopeptidase". Eur. J. Biochem. 190: 509–515. doi:10.1111/j.1432-1033.1990.tb15603.x. PMID 2373079.

External links

Prolyl aminopeptidase at the US National Library of Medicine Medical Subject Headings (MeSH)

Hydrolase: proteases (EC 3.4)

3.4.11-19: Exopeptidase

3.4.11	Aminopeptidase Alanine Arginyl Aspartyl Cystinyl Leucyl Glutamyl Methionyl 1 2 O

3.4.13	Dipeptidase 1 2 3

3.4.14	Dipeptidyl peptidase Cathepsin C Dipeptidyl peptidase-4 Tripeptidyl peptidase Tripeptidyl peptidase I Tripeptidyl peptidase II

3.4.15	Angiotensin-converting enzyme

3.4.16	Serine type carboxypeptidases: Cathepsin A DD-transpeptidase

3.4.17	Metalloexopeptidases Carboxypeptidase A A2 B C E Glutamate II

Other/ungrouped	Metalloexopeptidase

3.4.21-25: Endopeptidase

Other/ungrouped: Amyloid precursor protein secretase

3.4.99: Unknown

Staphylokinase

Proteins: enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

This article is issued from Wikipedia - version of the Tuesday, January 26, 2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.