Prostamide/prostaglandin F2alpha synthase

Prostamide/prostaglandin F2alpha synthase (EC 1.11.1.20, prostamide/PGF synthase, prostamide F synthase, prostamide/prostaglandin F synthase, tPGF synthase) is an enzyme with systematic name thioredoxin:(5Z,9alpha,11alpha,13E,15S)-9,11-epidioxy-15-hydroxy-prosta-5,13-dienoate oxidoreductase .^[1]^[2] This enzyme catalyses the following chemical reaction

thioredoxin + (5Z,9alpha,11alpha,13E,15S)-9,11-epidioxy-15-hydroxy-prosta-5,13-dienoate

\rightleftharpoons

thioredoxin disulfide + (5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxyprosta-5,13-dienoate

This enzyme contains a thioredoxin-type disulfide as a catalytic group.

References

↑ Moriuchi, H., Koda, N., Okuda-Ashitaka, E., Daiyasu, H., Ogasawara, K., Toh, H., Ito, S., Woodward, D.F. and Watanabe, K. (2008). "Molecular characterization of a novel type of prostamide/prostaglandin F synthase, belonging to the thioredoxin-like superfamily". J. Biol. Chem. 283 (2): 792–801. doi:10.1074/jbc.M705638200. PMID 18006499.
↑ Yoshikawa, K., Takei, S., Hasegawa-Ishii, S., Chiba, Y., Furukawa, A., Kawamura, N., Hosokawa, M., Woodward, D.F., Watanabe, K. and Shimada, A. (2011). "Preferential localization of prostamide/prostaglandin F synthase in myelin sheaths of the central nervous system". Brain Res. 1367: 22–32. doi:10.1016/j.brainres.2010.10.019. PMID 20950588.

External links

Prostamide/prostaglandin F2alpha synthase at the US National Library of Medicine Medical Subject Headings (MeSH)

Oxidoreductases: peroxidases (EC 1.11)

1.11.1.1-14	Catalase Cytochrome c peroxidase Eosinophil peroxidase Glutathione peroxidase GPX 1 2 3 4 5 6 7 8 Horseradish peroxidase Lactoperoxidase Myeloperoxidase Thyroid peroxidase Deiodinase Iodothyronine deiodinase Iodotyrosine deiodinase

1.11.1.15 (peroxiredoxin)	1 2 3 4 5 6

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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