Rubulavirus
| Rubulavirus | |
|---|---|
| Virus classification | |
| Group: | Group V ((-)ssRNA) |
| Order: | Mononegavirales |
| Family: | Paramyxoviridae |
| Subfamily: | Paramyxovirinae |
| Genus: | Rubulavirus |
| Type Species | |
Rubulavirus is a genus of viruses in the order Mononegavirales, in the family Paramyxoviridae, in the subfamily Paramyxovirinae. Humans, apes, pigs, and dogs serve as natural hosts. There are currently seven species in this genus, including the type species Mumps virus. Diseases associated with this genus include: mumps.[1][2]
Taxonomy
Group: ssRNA(-)
- Family: Paramyxoviridae
- Sub-Family: Paramyxovirinae
- Genus: Rubulavirus
- Human parainfluenza virus 2
- Human parainfluenza virus 4
- Mapuera virus
- Mumps virus
- Parainfluenza virus 5
- Porcine rubulavirus
- Simian virus 41
Related Viruses
The closest relations to this genus appear to be the avulaviruses.[3]
Structure
Viruses in Rubulavirus are enveloped, with spherical geometries. The diameter is around 150 nm. Genomes are linear, around 15kb in length. The genome codes for 8 proteins.[1]
| Genus | Structure | Symmetry | Capsid | Genomic Arrangement | Genomic Segmentation |
|---|---|---|---|---|---|
| Rubulavirus | Spherical | Enveloped | Linear | Monopartite |
Life Cycle
Viral replication is cytoplasmic. Entry into the host cell is achieved by virus attaches to host cell. Replication follows the negative stranded RNA virus replication model. Negative stranded RNA virus transcription, using polymerase stuttering, through co-transcriptional RNA editing is the method of transcription. The virus exits the host cell by budding. Humans, apes, pigs, and dogs serve as the natural host. Transmission routes are respiratory and saliva.[1]
| Genus | Host Details | Tissue Tropism | Entry Details | Release Details | Replication Site | Assembly Site | Transmission |
|---|---|---|---|---|---|---|---|
| Rubulavirus | Humans; apes; pigs; dogs | None | Glycoprotein | Budding | Cytoplasm | Cytoplasm | Aerosols; saliva |
References
- 1 2 3 "Viral Zone". ExPASy. Retrieved 13 August 2015.
- 1 2 ICTV. "Virus Taxonomy: 2014 Release". Retrieved 13 August 2015.
- ↑ McCarthy AJ, Goodman SJ (2010) Reassessing conflicting evolutionary histories of the Paramyxoviridae and the origins of respiroviruses with Bayesian multigene phylogenies. Infect Genet Evol 10(1):97–107
External links
- Viralzone: Rubulavirus
- ICTV
- http://www.biology-online.org/dictionary/Rubulavirus
- Virus Pathogen Database and Analysis Resource (ViPR): Paramyxoviridae
- Rubulavirus on ExPASy Proteomics from the Swiss Institute of Bioinformatics